Electrical stimulation therapy improves sleep respiratory parameters in obstructive sleep apnea syndrome: A meta-analysis

Abstract

Recent clinical trials have shown that electrical stimulation has beneficial effects in obstructive sleep apnea syndrome (OSAS). The purpose of this study was to evaluate the efficacy of electrical stimulation therapy for OSAS with a meta-analysis. The meta-analysis of all relative studies was performed through searching international literature, including PUBMED, CNKI, and EMBASE databases. This literature analysis compared all patients undergoing electrical stimulation therapy with respect to the respiratory disturbance index (RDI) and changes in sleep structure. Six studies were selected involving a total of 91 patients. The meta-analysis indicated that electrical stimulation therapy reduced RDI, longest apnea time, and improved the minimum SaO₂. Based on the evidence found, electrical stimulation may be a potential therapy for OSAS, warranting further clinical trials.

Keywords

obstructive sleep apnea syndrome / electrical stimulation / meta-analysis

References

[1] Alvarez-Sala WaltherJL. Obstructive sleep apnea syndrome. An R Acad Nac Med (Madr), 2002, 119(1): 197-211

[2] LudwigA. Results of electromyostimulation therapy in obstructive sleep apnea. Artif Organs, 2008, 32(8): 655-658

[3] FavaC, MontagnanaM, FavaloroEJ, et al.. Obstructive sleep apnea syndrome and cardiovascular diseases. Semin Thromb Hemost, 2011, 37(3): 280-297

[4] EpsteinLJ, KristoD, StrolloPJ, et al.. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med, 2009, 5(3): 263-276

[5] The Cochrane Collaboration. Cochrane Handbook for Systematic Reviews of Interventions (4.2.6) [EB/OL]. www.cochrane.org/resources/handbook/Handbook4.2.6Sep2006.pdf, 2007-11-08.

[6] JadadAR, MooreRA, CarrollD, et al.. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials, 1996, 17(1): 1-12

[7] CarterAO, GriffinGH, CarterTP. A survey identified publication bias in the secondary literature. J Clin Epidemiol, 2006, 59(3): 241-245

[8] BeggCB, MazumdarM. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101

[9] EggerM, Davey SmithG, SchneiderM, et al.. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634

[10] YangH, MengXG, ZhuYZ. Clinical study of effects of submaxillary transcutaneous electrical stimulation of genioglossus on obstructive sleep apnea syndrome. Lin Chuang Er Bi Yan Hou Ke Za Zhi (Chinese), 2000, 14(6): 250-252

[11] PiaoS, HeYF, YuanF. Influence of the transcutaneous electrical stimulator for OSAS. Zhonghua Jiehe Yu Huxi Zazhi (Chinese), 1998, 21(8): 492-493

[12] YangH, MengXG, TanXM. Observation of the effect of treatment on submaxillary transcutaneous electrical stimulation of 23 cases with obstructive sleep apnea syndrome. Chongqing Yixue (Chinese), 2004, 33(2): 232-234

[13] HuLG, XuXM, GongYS. Experimental study of non-invasive percutaneous electrical stimulator for treatment of obstructive sleep apnea syndrome and its clinicale effect. J BioMed Eng, 2006, 23(4): 852-855

[14] LequeuxT, ChantrainG, BonnandM, et al.. Physiotherapy in obstructive sleep apnea syndrome: preliminary results. Eur Arch Otorhinolaryngol, 2005, 262(6): 501-503

[15] MikiH, HidaW, ChonanT, et al.. Effects of submental electrical stimulation during sleep on upper airway patency in patients with obstructive sleep apnea. Am Rev Respir Dis, 1989, 140(5): 1285-1289

[16] SchwartzAR, BennettML, SmithPL, et al.. Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg, 2001, 127(10): 1216-1223

[17] HudgelDW, ThanakitcharuS. Pharmacologic treatment of sleep-disordered breathing. Am J Respir Crit Care Med, 1998, 158(3): 691-699

[18] LiWY, ZhangLS, NiDF, et al.. Nasopharyngeal stenosis following uvulopalatopharyngoplasty. Linchuang Erbiyanhou Ke Zazhi (Chinese), 2000, 14(2): 53-54