Toxicological studies on the organophosphorous insecticide methyl-ISP

Abstract

Methyl-ISP, a newly developed organophosphorous insecticide, is used in China to treat and protect plants from pest infestation. Our studies demonstrated that methyl-ISP is metabolized rapidly in tat and mouse. Its toxicity was low. no obvious accumulative toxicity, chronic toxicity, teratogenicity, mutagenicity, reproductive toxicity or delayed neuirotoxicity could be observed. It is therefore concluded that methyl-ISP is relatively safe to animals and human subjects. methyl-ISP is now employed to replace the other commonly used insecticide hexachlorobenzene (666) in agriculture. A preliminary study was performed to elucidate the mechanism of intoxication at subcellular levels.

Keywords

methyl-ISP / toxicity of insecticide / delayed neurotoxicity / pharmacokinetics / microsomal enzymes / mitochondria

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