The role of lipoprotein lipase in metabolism of normolipidemic very low density lipoprotein by macrophages

Abstract

It was demonstrated by using lipoprotion lipase (LFL) inhibition benzene boronic acid (BBA) that LFL played a major role in the accumulai on of triglycerides (TG) in mouse peritoneal macrophages exposed to rabbit rormal vevy low density lipoproteins (N-VLDL). These were less free fatty acids (FFA) and much more N-VLDL-TG left in the media containing BBA than in the controls. TG accumulation in the cells was greatly diminished or even prohibited by BBA. Thus, we obtained direct evidence that LPL played a mole important role than the leceptor did in the uptake of N-VLDL-TG by mouse macrophages. The mechanisms of LPL action were discussed.

Keywords

LPL / N-VLDL / macrophage / triglyccride

References

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