An immunoelectron microscopic study of peptide substances in the rat neurohypophysis
Chang-geng Zhu , A-qing Chen , Qing-ying Liu , Ying Wei , Xuan-lin Peng
Current Medical Science ›› 1989, Vol. 9 ›› Issue (1) : 29 -35.
An immunoelectron microscopic study of peptide substances in the rat neurohypophysis
The ultrastructural localization of peptide substances, such as vascpressin (VP) substance P (SP), enkephalin (ENK) and somatostatin (SRIF), and the distribution of peptidergic nerves in rat neurohypephysis were studied by immunoelectron microscopy. The results show that VP, SP, ENK and SRIF immunoreactive products are located in large granular vesieles (110–150 nm in diameter), at the periphery of microvosieles and on the outer membrane of mitochondria. The VP-, SP-, ENK -and SRIF-containig nerve fibers are distributed at the pcriphery of capillaries and in the vicinity of pituicytes. VP -and ENK-positive nerve terminals form a xo-a xonie synapses with negative terminals. VP -and ENK-terminals are pre-or postsynaptic elements. Axo-a xonic synapses formed by two SRIF-positive terminals were also found. In addition, ENK -and SP-positive terminals with pituicytes form synaptoid structures respectively. The authors have discovered VP-positive pituicytes for the first time.
neurohypophysis / immuno cytochemistry / peptides / rat
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