Immunohistochemical research on HDV infection in Chinese patients with chronic liver disease

Abstract

The prevalence of HDAg in the liver of Chinese patients with chronic hepatitis and hepatocellular carcinoma was determined by using direct immunofluorescence and immunoperoxidase. Six patients (6.3 %) out of 95 HBsAg carriers with inflammatory liver disease and neoplasia were found to be HDAg positive. HDAg was shown in the liver of 6 patients (7.6 %) among 79 patients with chronic hepatitis. The relative frequency of HDAg in cinhosis-B, chronic active hepatitis B and chronic persistent hepatitis B was 14.3 %, 7.1% and 5.9% respectively. These results suggest that a sizeable number of HBsAg carriers are superinfected with HDV. In view of the large amount of HBV carriers in China, the relative minor but distinct presence of HDV poses an important community health problem.

Keywords

HDV / HDAg / superinfection / immunohistochemistry

References

[1] RoggendorfM, et al. , et al. . RizzettoM, et al. , et al. . Prevalence of hepatitis delta virus infection in different provinces of China. The Hepatitis Delta Virus and Its Infection, 1987, New York, A.R. Liss: 487-91

[2] GmelinK, et al. . Antibodies to hepatitis delta virus can not be detected in carriers of hepatitis B surface antigen in Wuhan area (PR China). J Tongji Med Univ, 1986, 6: 198-198

[3] XuJY, XieYB, et al. . VermeG, et al. . Delta infection in Chinese carriers of the HBsAg. Viral Hepatitis and Delta Infection, 1983, New York, A.R. Liss: 295-6

[4] Mai K, et al. A study on hepatitis D virus infection in China. In: Zuckerman ed. Selected Abstracts Submitted for the 1987 International Symposium on Viral Hepatitis and Liver Disease, May1987 London. 32A.

[5] HaoLJ, ZhangYY. Vorläufige Untersuchung des Delta-Agens im Lebergewebe von Patienten mit Virushepatitis B. Acta Acad Med Wuhan, 1985, 5: 107-11

[6] LuIJ, et al. , et al. . RizzettoM, et al. , et al. . Delta agent infection in Taiwan. The Hepatitis Delta virus and Its Infection, 1987, New York, A.R. Liss: 485-485

[7] LiawYF, et al. , et al. . RizzettoM, et al. , et al. . Hepatitis delta virus infection in Taiwan. The Hepatitis Delta Virus and Its Infection, 1987, New York, A.R. Liss: 479-83

[8] ChuCM, et al. . The role of delta superinfection in acute exacerbation of chronic type B hepatitis. Liver, 1985, 6: 26-9

[9] Tsai YT, et al. Hepatitis D virus infection in an endemic area of hepatitis B infection a seroepidemiologic study (Abstract). International Symposium on Chronic Hepatitis, Taipei, Taiwan, 1985:34.

[10] GovindarajanS, et al. . Prevalence of delta agent among Chinese in Taiwan and Los Angeles. J Med Virol, 1984, 14: 33-7

[11] ChenDS, et al. . Delta agent infection in patients with chronic liver disease and hepatocellular carcinoma an infrequent finding in Taiwan. Hepatology, 1984, 4: 502-3

[12] RizzettoM, et al. . Epidemiology ofHBV associated delta agent: Geographic distribution of anti-delta and prevalence in poly-transfused HBsAg carriers. Lancet, 1980, I: 1215-9

[13] RizzettoM, et al. . Chronic hepatitis in carriers of hepatitis B surface antigen with intrahepatic expression of the delta antigen. Ann Inter Med, 1983, 98: 437-41

[14] RizzettoM.. The delta agent. Hepatology, 1983, 3: 729-37