Hb Ottawa [α15(A13) GLY→ARG] found in Hubei Province, People’s Republic of China

Gu Yuan-chao; J. B. Wilson; B. B. Webber; T. H. J. Huisman; Wang Bi-yu; Lo Yiqin; Liu Kang; Meng Bing; Yuan Yu-ru

doi:10.1007/BF02911459

Current Medical Science ›› 1986, Vol. 6 ›› Issue (3) : 185 -187. DOI: 10.1007/BF02911459

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Hb Ottawa [α15(A13) GLY→ARG] found in Hubei Province, People’s Republic of China

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Abstract

The slow-moving hemoglobin variant Hb Ottawa or α₂ 15(A13) Gly→Argβ₂ was found in a heterozygote living in Hubei Province, People’s Republic of China. Structural characterization made use of high performance liquid chromatography (HPLC) and sequence analysis with the ultra micro-DABITC/PITC double coupling method.

Keywords

Hb Ottawa / hemoglobin / heterozygote / high performance liquid chromatography (HPLC) / reverse phase HPLC / DABITC/PITC double coupling method

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Gu Yuan-chao, J. B. Wilson, B. B. Webber, T. H. J. Huisman, Wang Bi-yu, Lo Yiqin, Liu Kang, Meng Bing, Yuan Yu-ru. Hb Ottawa [α15(A13) GLY→ARG] found in Hubei Province, People’s Republic of China. Current Medical Science, 1986, 6(3): 185-187 DOI:10.1007/BF02911459

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References

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[2]	PootrakulS, et al. . Hemoglobin Siam (α₂ 15 Arg β2): A new a chain variant. Humangenetik, 1974, 23: 199-199

[3]	YangK, et al. . Structural analysis of a case of Hb Ottawa. Acta Biochim Biophys Sin, 1984, 16(5): 467-467

[4]	1981;3:56–60.

[5]	HuismanTHJ, JonxisJHP. The Hemoglobinopathies-Techniques of Identification, 1977, New York, Marcel Dekker Inc

[6]	WilsonJB, et al. . Separation of the tryptic peptides of normal and abnormal α, gb, γ, and δ hemoglobin chains by high-performance liquid chromatography. J Chromatogr, 1979, 179: 271-271

[7]	ChangJY, et al. . Micro-sequence analysis of peptide and protein using 4-NN-dimethylaminoazobenzene 4′-isothiocyanate/phenylisothiocyanate double coupling method. FEBS Lett, 1978, 93: 205-205