Distribution and excretion of3H-rhomotoxin in mice
Liu Yong-jia , Wang Ya-zhen , Mao Huan-yuan , Guo He-ping , Liu Shu-mao , Cai Xi-lin , Cai Yi-hua , Shen De-cun , Sun Jia-xiu , Sun Zhi-wei
Current Medical Science ›› 1986, Vol. 6 ›› Issue (3) : 172 -175.
Distribution and excretion of3H-rhomotoxin in mice
The distribution and excretion of intravenous injected3H-rhomotoxin was studied in mice. The radioactivity of3H-rhomotoxin was found to be high in gall bladder, liver and kidney, lower in thyroid gland, adrenal gland, heart and lungs, and lowest in brain. 52.4% of the drug was excreted in urine and feces within 6 h. Rhomotoxin was bound to plasma protein (60 % at 30 min) and to some extent to liver and kidney tissue.
rhomotoxin / radioactivity / binding rate
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