Distribution and excretion of³H-rhomotoxin in mice

Abstract

The distribution and excretion of intravenous injected³H-rhomotoxin was studied in mice. The radioactivity of³H-rhomotoxin was found to be high in gall bladder, liver and kidney, lower in thyroid gland, adrenal gland, heart and lungs, and lowest in brain. 52.4% of the drug was excreted in urine and feces within 6 h. Rhomotoxin was bound to plasma protein (60 % at 30 min) and to some extent to liver and kidney tissue.

Keywords

rhomotoxin / radioactivity / binding rate

References

[1] 979;8(l):45–6.

[2] 1979;8(l):44.

[3] 1981;1(3):7–9.

[4] MaoH Y, et al. . Rhomo toxin pharmacologic action in lowering blood pressure and slowing heart rate. Chin Med J, 1982, 95(5): 311-8

[5] 1979; 7(2): 125–7.

[6] 1981; 10 (l):82–7.

[7] 1981;10(l):88–90.

[8] MaoHY, et al. . Rapid antihypertensive effect of rhomotoxin in 105 hypertension cases. Chin Med J, 1981, 94(11): 733-6

[9] 1979;7(2):91–4.

[10] 1980;9(1):77–81.

[11] 1981:10(l):91–2.

[12] 175–12 1981; 12(2):26.

[13] 1982; 3(1):62–4.