Application of quantitative determination of urinary proteins in the diagnosis of acute rejection following renal transplantation

Abstract

Eight kinds of urinary proteins were determined after renal transplantation. The results demonstrated that the concentrations of 8 urinary proteins were markedly increased when acute rejection occurred. Increase in urinary proteins was noticed 0–7 days prior to establishment of clinical diagnosis. Of the 8 urinary proteins IgG and transferrin appeared first. The positive rates of IgG and C₃, both being 93 %, were the highest among them. Provided the antirejection treatment was effective, the concentration of urinary proteins would drop rapidly, otherwise it would remain at high levels.

Keywords

proteinuria / renal transplantation / diagnosis of acute rejection

References

[1] SethiK, et al. . Proteinuria following renal transplantation. Nephron, 1975, 18: 49-49

[2] FreyBM, et al. . Proteinurie nach Nierentransplantation. Schweiz Med Wochenschr, 1977, 107: 1181-90

[3] KwunKB, et al. . Persistent immunoglobulinuria in irreversible renal allograft rejection in humans. Transplantation, 1977, 24: 453-7

[4] WellwoodJM, et al. . Evidence of gentamicin nephrotoxicity in patients with renal allograft. Br Med J, 1975, 3: 278-81

[5] HoqMS, et al. . Urinary excretion of fibrinogen-related materials, complement, and immunoglobuline in proliferative glomerulonephritis and after renal transplantation. Br Med J, 1974, 2: 535-8

[6] Anderton JL, et al. Dialysis transplantation nephrology. Tunbrige Wellsi Pitman Medical 1978;342.