The morphological spectrum of peripheral intrahepatic cholangiocarcinoma — An attempt at histological classification on twenty-eight autopsy cases

Abstract

From 91,725 autopsies, 28 cases of peripheral intrahepatic cholangiocarcinoma were selected to study the wide spectrum of histopathology of the tumor. The results showed that two cases (7.14 %) had predominantly solid type. One case had pure, and six had predominant cordai type (25%). Four showed pure, another four showed predominant ductal type (28.57%). Six (21.43%) revealed glandular pattern, one of which consisted of this pure component. Fapillary type was present in three cases (10.71 %) with two entirely made of this conformation. One case (3.57%) was classified as adenosquamous type and another one (3.57%) fell into the undifferentiated category. No obvious correlations between histological subtypes and underlying liver disease, stroma reaction or biological behaviour have been found. The significance of the classification in the tumor diagnosis and differential diagnosis, as well as possible mechanisms of carcinogenesis in these patients are discussed.

Keywords

pathology / peripheral cholangiocarcinoma / histological classification

References

[1] EdmondsonHA, PetersRL. SchiffL, SchiffER. Neoplasms of the liver. Diseases of the liver, 1982, Philadelphia, Lippincott: 1101-58

[2] MoriW, NagasakoK. OkudaK, PetersRL. Cholangiocarcinoma and related lesions. Hepatocellular carcinoma, 1976, Chicago, Wiley: 227-46

[3] McSweenRNM. A clinicopathological review of 100 cases of primary malignant tumors of the liver. J Clin Pathol, 1974, 27: 669-82

[4] BelamaricJ. Intrahepatic bile duct carcinoma and C. sinensis infection in Hong Kong. Cancer, 1972, 30: 468-73

[5] StitnimankarnT, et al. . Ultrastructure of cholangiocarcinoma associated with opisthorchiasis. Southeast Asian J Trop Med Pub Health, 1978, 9: 558-66

[6] EdmondsonHA, SteinerPE. Primary carcinoma of the liver: a study of 100 cases among 48900 neuropsies. Cancer, 1954, 7: 462-503

[7] SteinerPE, HigginsonJ. Cholangiolocellular carcinoma of the liver. Cancer, 1959, 12: 753-9

[8] KlatskinG. Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis: an unusual tumor with distinctive clinical and pathological features. Am J Med, 1965, 38: 241-56

[9] AlpertLI, et al. . Cholangiocarcinoma: a clinicopathologic study of five cases with ultrastructural observations. Human Pathol, 1974, 5: 709-28

[10] Gibson JB, Sobin LH. Types histologiques des tumeurs du foie, des voies biliaires et du pancreas. Geneve; Organisation Mondiale de la Sante, 1978:23–30.

[11] HouFC. The relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis. J Pathol Bacteriol, 1956, 122: 239-46

[12] BlousteinPA, SilverbergSG. Squamous cell carcinoma originating in a hepatic cyst. Cancer, 1976, 38: 2002-5