Evaluation of the effects of tetrandrine on experimental myocardial ischemic and infarct size by cardiothermography

Abstract

This experimental observation from 46 anesthetized open chest dogs suggested that cardiothermography is a reliable method for determining moment to moment charges in the extent of myocardial ischemia. Taking the extent of cold area in cardiothermography instantly following the 1st ligation of the left anterior descending artery as 100%, it was 59.63 % in T₃ group (tetrandrine 3 mg/kg), 81.74 % in T₅ group (tetrandrine 5 mg/kg), 100.7 % in propranolol group (propranolol 0.5 mg/kg), and 128 % in control group 30 min after treatment. The cold area detected by cardiothermography coincided with the results of epicardial mapping and TTC staining. The ischemic and infarct size evaluated by these 3 methods showed that tetrandrine had definite protective effects on myocardial ischemia with reduction of infarct size.

Keywords

thermography / cardiothermography / tetrandrine / experimental myocardial ischemia

References

[1] 1983;11 (2): 147–9.

[2] Ribeiro LGT, et al. Influence of the extent of the zone at risk on the effectiveness of drugs in reducing infarct size. Circulation 1982;(1): 181–6.

[3] CordayE, et al. . Interventions that might influence viability of ischemic jeopardized myocardium. Am J Cardiol, 1976, 37(4): 461-5

[4] JenningsRE, et al. . Structural changes in myocardium during acute ischemia. Circ Res, 1974, 35(Suppl III): 156-60

[5] TzivoniD, et al. . Evaluation of changes in epicardial blood flow in experimental animals by cardiothermography. Eur Heart J, 1982, 3: 383-8

[6] MalmA, et al. . Effects of nitroglycerin and dipyridamole on acute myocardial infarction; a thermographic study in the dog. Cardiovasc Res, 1979, 13: 281-7

[7] MalmA, et al. . Effects of oxygen on acute myocardial infarction: a thermographic study in the dog. Cardiovasc Res, 1977, 11: 512-8

[8] MarokoPR, et al. . Factors influencing infarct size following experimental coronary artery occlusion. Circulation, 1971, 43: 67-81

[9] FishbeinMC, et al. . Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J, 1981, 101(5): 593-9

[10] 1980;8(4): 303–7.

[11] 1981;16: 287–91.

[12] 1983;63(12): 772–4.

[13] FoxK, et al. . Myocardial infarction in the dog: Effects of intravenous propranolol. Am J Cardiol, 1980, 45: 769-74