Immunohistological study on the mechanism of mesangial proliferation

Abstract

Inflammatory cells infiltrated in glomeruli and proliferating glomerular cells were immunohistochemically studied in 87 renal biopsies from patients with glomerulonephritides (GN) of various types, by using monoclonal antibody to Mac387 and PCNA (proliferative cell nuclear antigen) respectively. The results showed that the expressions of Mac387 and PCNA were generally increased in proliferative GN, compared with non-proliferative GN. The expression of Mac 387 was related to the severity of mesangial cell proliferation determined by light microscopy, but the increase of PCNA expression was found in severely proliferative GN. Although certain relationship between Mac387 and PCNA expression on glomerular cells was observed, it was not statistically significant. Finally, the possible mechanism of glomerular mesangial proliferation was discussed.

Keywords

mesangial proliferation / glomerulonephritis / immunohistochemistry

References

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