Study on the p53 protein expression in gastric cancer and precancerous lesions by flow cytometry

Abstract

At present, p53 gene and its product p53 protein are the hot spot in the field of cancer research. 50% human malignant tumors are associated with p53 alteration. p53 gene mutation is the most common mutation, which can lead to regulation disturbance of cell proliferation. Gastric cancer is the most common disease in China. Its incidence is the second among various malignant tumors. There were reports about p53 protein expression and gastric cancer progression but few report on p53 protein expression in different stages of precancerous lesions was available. In this study, we analyzed p53 protein expression in gastric cancer and precancerous lesions by flow cytometry to evaluate the role of p53 protein in the pathogenesis of gastric cancer.

Keywords

p53 protein expression / gastric cancer / precancerous lesions / flow cytometry