Infectivity and risk factors of hepatitis C virus transmission through sexual contact

Abstract

HCV infection among heterosexuals with multiple partners and family members of patients with hepatitis C, and HCV RNA in the body fluid of these patients were investigated. The results showed that the HCV infection in heterosexuals with multiple partners, which was related to sexual activity, was much higher than that of healthy pregnant women. The HCV RNA in the saliva, semen or vaginal discharge of patients with hepatitis C was at detectable level. Among the patient’s relatives, none of the children but 2 spouses were found to be infected with HCV. We concluded that sexual contact might play some role in HCV transmission.

Keywords

HCV / sexual contact transmission

References

[1] AlterM J, SamplinerR E. Hepatitis C and miles to go before we sleep. N Engl J Med, 1989, 321: 1538-1538

[2] AlterM J, ColemanP J, AlexanderW J, et al.. Importance of heterosexual activity in the transmission of hepatitis B and non-A, non-B hepatitis. JAMA, 1989, 262: 1201-1201

[3] AlterM J, HadlerS C, JudsonF N, et al.. Risk factors for acute non-A, non-B hepatitis in the United States and association with hepatitis C virus infection. JAMA, 1990, 264: 2231-2231

[4] RNA 1995, 24(5): 320.

[5] van DoornumG. J. J., HooykaasC., CuypersM T, et al.. Prevalence of hepatitis C virus infections among heterosexuals with multiple partners. J Med Virol, 1991, 35: 22-22

[6] NakashimaK, KashiwagiS, HayashiS, et al.. Sexual transmission of hepatitis C virus among female prostitutes and patients with sexually transmitted disease in Fukuoka, Kyashu, Japan. Am J Epidemiol, 1992, 136: 1132-1132

[7] MelbyeM, BiggarR J, WantzinP, et al.. Sexual transmission of hepatitis C virus: cohort study (1981–9) among European homosexual men. BMJ, 1990, 301: 210-210

[8] WuJ C, LinH C, JengF S, et al.. Prevalence, infectivity and risk factor analysis of hepatitis C virus infection in prostitutes. J Med Virol, 1993, 39: 312-312

[9] TabetS R, PolmerD L, WieseW H, et al.. Seroprevalence of HIV I and hepatitis B and C in prostitutes in Albuquerque, New Mexico. Am J Public Health, 1992, 82: 1151-1151

[10] KrygerP, PedersenN S, MathiesenL, et al.. Increased risk of infection with hepatitis A and B viruses in men with a history of syphilis: relation to sexual contacts. J Infect Dis, 1982, 45: 23-23

[11] RosenblumL S, HadlerS C, CastroK G, et al.. Heterosexual transmission of hepatitis B virus in Belle Glade, Florida. J Infect Dis, 1990, 161: 407-407

[12] LiuT C, ChangT T, YoungK L, et al.. Detection of HCV-RNA in saliva, urine, seminal fluid and ascites. J Med Virol, 1992, 37: 197-197

[13] HondM, KanekoS, UnouraM, et al.. Risk of hepatitis C virus infections through household contact with chronic carriers: analysis of nucleotide sequence. Hematology, 1993, 17(6): 971-971