Additional pathological features in epileptic patients secondary to brain tumors — A report of 50 cases

Abstract

Not only is surgery a better therapy for intractable seizures, but it may also open up the possibilities of further revealing the mysteries of epilepsy by pathologic observation. The present study covered 50 cases of drug-resistant seizures due to brain tumors verified ty operation. Apart from the morphological changes directly related to brain tumors, there appeared to be some additional pathologic features, which could be grouped under four heads, i.e., cortical architectural and neuronal abnormalities, large malformations, pathologic changes in or adjacent to the tumor tissue, and other abnormalities. In the present paper the questions as to the pathogenesis of seizures [and the origin of tumors are discussed. The results of our study suggest that the coexistence of neoplastic transformation and histo-architectural abnormalities might be a morphologic feature in cases of brain gliomas associated with seizures.

Keywords

intractable seizures / primary brain tumor / corticectomy / lobectomy / pathological features

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