Altered lymphocyte subsets and natural killer cells of patients with obstructive jaundice in perioperative period

Abstract

Sepsis is a common and occasionally lethal complication of obstructive jaundice. The reasons for the increased susceptibility to infection are not fully understood. This study was conducted to examine lymphocyte subsets and natural killer cells of patients with obstructive jaundice in perioperative period. In these patients, when compared with normal controls, there was a significant reduction in the percentage of Leu 4 (pan T lymphocytes), Leu 3a (T helper cells) and Leu 7 (natural killer cells) before operation, and the immune suppression induced by surgical operation was more marked and persistent.

Keywords

obstructive jaundice / perioperative period / lymphocyte subsets / natural killer cells

References

[1] VaneDW, et al.. Impaired immune function in obstructive jaundice. J Surg Res, 1988, 45: 287-93

[2] FellerAC. Monoklonale Antikörper in der Diagnostik maligner Lymphome. Diagnose & Labor, 1985, 35: 23-35

[3] 1987; 7:73–6.

[4] BongersV, BertramsJ. The influence of common variables on T cell subset analysis by monoclonal antibodies. J Immunol Methods, 1984, 67: 243-55

[5] ZaleznikDF, et al.. A soluble suppressor T-cell factor protects against experimental intraabdominal abscesses. J Clin Invest, 1985, 75: 1023-7

[6] HansbroughJF, et al.. Altered helper and suppressor lymphocyte populations in surgical patients. Am J Surg, 1984, 148: 303-7

[7] O’MahonyJB, et al.. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma, 1984, 24: 869-75

[8] LennardTWJ, et al.. The influence of surgical operations on components of the human immune system. Br J Surg, 1985, 72: 771-6