Immunohistochemical detection of HBsAg and HBcAg in the liver of patients with schistosomiasis japonica complicated by hepatocellular carcinoma

Abstract

In liver biopsies from 21 patients with schistosomiasis japonica complicated by hepatocellular carcinoma (HCC), 69 patients with advanced schistosomiasis japonica, and 25 patients with HCC, HBsAg and HBcAg were investigated with peroxidase-antiperoxidase technique. The positive rate of HBAg (i.e. HBsAg and/or HBcAg) in the liver of patients with schistosomiasis japonica complicated by HCC was significantly higher than in the group of advanced schistosomiasis japonica, but similar to that in cases of HCC. The location of carcinoma cells in the liver was not related to the distribution of schistosomial ova in patients with schistosomiasis japonica complicated by HCC. The results indicated that the complication with hepatitis B virus infection may be one of the major factors involved in the development of HCC in patients with schistosomiasis japonica.

Keywords

schistosomiasis japonica / hepatocellular carcinoma / hepatitis B / HBsAg / HBcAg

References

[1] NakashimaT, et al.. Primary liver cancer coincident with schistosomiasis japonica. A study of 24 biopsies. Cancer, 1975, 36: 1483-9

[2] 1963:170.

[3] InabaY, et al.. A case-control study on liver cancer with special emphasis on the possible aetiological role of schistosomiasis. Int J Epidemiol, 1984, 13: 408-12

[4] 1987;5: 220–3.

[5] InabaY, et al.. Liver cancer in an endemic area of schistosomiasis japonica in Yamanashi Prefecture, Japan. Inst Symp Princess Takamatsu Cancer Res Fund, 1987, 18: 211-211

[6] UetsujiS, et al.. Primary liver cancer coincident with schistosomiasis japonica. Gan No Kinsho, 1990, 36: 521-521

[7] LyraLG, et al.. Hepatitis B surface antigen carrier state in hepatosplenic schistosomiasis. Gastroenterology, 1976, 71: 614-5

[8] 1988:68:98.

[9] 1979: 106.

[10] 1982:62:257.

[11] ShafritzDA. Role of various molecular forms of HBV-DNA in chronic liver diseases and primary liver cancer. Hepatology Rap Lit Rev, 1987, 17: 51-51

[12] NashTE, et al.. Schistosome infection in humans: perspectives and recent findings. Ann Intern Med, 1982, 97: 740-740

[13] 1986;15(2):101–4.