Analysis of plasma fibrinolysis in the patients with acute cerebral infarction

Abstract

In the present study, the plasma fibrinolytic activity in 30 cases of corticaloartery territory cerebral infarction (CACI) and 32 cases of perforating artery territory cerebral infarction (PACI) within 3 days after ictus, and 30 sex- and age-matched controls without cardio-cerebrovascular diseases were evaluated by a comprehensive panel of assay, including the plasma tPA activity, PAI activity, endothelial capacity of tPA release and PAI/tPA ratio. The results showed that the plasma fibrinolysis and the endothelial potential to release tPA responding to stimulation in bcoch subtypes of the patients were significantly lower than those in the controls, which provide the theoretical basis for carrying out the thrombolytic therapy in the ischemic stroke. And the study also suggested that increased plasma PAI activity could increase the risk of AS chrombotic events with increased serum triglyceride level.

Keywords

cerebral infarction / tissue-plasminogen activator (tPA) / plasminogen activator inhibitor (PAI)

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