Effects of thyrotropin-releasing hormone on cardiovascular function in dogs with hemorrhagic shock

Abstract

The beneficial effects of TRH i.v. on cardiovascular function in dog hemorrhagic shock were proved in this paper. CI, SVI, RVSVI, BP, and especially LVSVI were significantly improved after administration of TRH. By observing microcirculation in the bulbar conjunctiva it was found that the venules dilated, the velocity of blood flow increased and aggregation of red blood cells decreased. In addition, acidosis during shock was attenuated. The 24 h survival rate was improved and survival time prolonged, but activity of lysosomal enzymes was not significantly changed.

Combination of TRH with dexametharone did not show additional advantages in the treatment of hemorrhagic shock.

Keywords

thyrotropin-releasing hormone (TRH) / hemorrhage / shock / cardiovascular function

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