Significance of changes in plasma atrial natriuretic peptide in congestive heart failure

Abstract

Plasma atrial natriuretic peptide (pANP) levels were measured in 60 patients with congestive heart failure (CHF) and 69 healthy subjects. Another 29 cardiopathic patients without any sign of CHF also underwent hemodynamic and pANP determination simultaneously. The results showed that the majority of patients with CHF had an elevation of pANP level, but a few patients with serious clinical condition showed lower pANP levels than the controls. pANP levels fell remarkably with the improvement of clinical stale after treatment. A correlation was observed between pANP and right atrial pressure or pulmonary capillary wedge pressure. The mechanisms and clinical significance of changes in pANP in CHF were discussed.

Keywords

congestive heart failure / atrial natriuretic peptide / hemodynamics / urinary sodium excretion

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