Effects of intracerebroventricular microinjection of angiotensin III on the cardiovascular activities in rabbits

Abstract

In mongrel rabbits intracerebroventricular microinjected angiotensin III (A III, 4 nmol) and angiotensin II (A II 4 nmol) equally evoked increase of mean arterial pressure and decrease of heart rate respectively. However, intracerebroventricular preinjection of saralasin, prazosin or arginine-vasopressin antiserum or intravenous preinjection of phentolamine could markedly attenuate the above cardiovascular effects of A III and A II respectively. The results indicated that the response intensity and mechanism of the central presser effect of A III were similar to those of A II.

Keywords

angiotensin II / angiotensin III / cardiovascular regulation / saralasin / prazosin

References

[1] Sawyer H, et al. The rabbit diencephalon in stereotaxic coordinates. Comp Neurol 1954:101.

[2] 1982;13:180–1.

[3] WrightJW, et al.. Central angiotensinI induced dipsogenicity in rats and gerbils. Brain Res, 1984, 295: 121-6

[4] ReidIA. Actions of angiotensinI on the brain: mechanisms and physiologic role. Am J Physiol, 1984, 246: F533-43

[5] LumbersER, et al.. Inhibition of the vagal component of the baro-receptorcardioinhibitory reflex by angiotensinI in dogs and sheep. J Physiol, 1983, 336: 83-9

[6] ZimmermanE, et al.. Vasopressin and oxytocin in the central nervous system. Fed Proc, 1984, 43: 91