Response of melanoma cells to α- MSH and cAMP stimulation

Liu Yun-hua

doi:10.1007/BF02887801

Current Medical Science ›› 1988, Vol. 8 ›› Issue (2) DOI: 10.1007/BF02887801

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Response of melanoma cells to α- MSH and cAMP stimulation

Liu Yun-hua ¹

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Abstract

A melanotic clone of the Claudmann S-91 melanoma was treated with 2 × 10^™7M α-MSH and 10^™3M cAMP. By fluorometric assay and electron microscopy it was found that these agents enhanced melanin content and melanosomes in cytoplasm, inhibited cell growth and incuced morphologic alterations, such as appearance of hypertrophy and dendrite-like formation.

Keywords

α-MSH / cAMP / melanoma cells

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Liu Yun-hua. Response of melanoma cells to α- MSH and cAMP stimulation. Current Medical Science, 1988, 8(2): DOI:10.1007/BF02887801

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