Analysis of the biocompatibility of magnetic porous tricalcium phosphate ceramics in rat femurs

Abstract

A new biomaterial, magnetic porous tricalcium phosphate ceramics (MPTCP), may be used for repairing defects in bones as a substitute for bone grafting. This study was designed to examine its biocompatibility and the systemic toxicity. The ceramic sections, approximately 15.3 mg, were implanted into both proximal femurs of 10 male and 10 female albino SW rats. An equal number of male and female animals served as sham-operated controls. Implantation of MPTCP ceramics in rat femurs had no deleterious effects on body weight, organ/body weight ratio, and on blood, liver and kidney functions. Plasma levels of inorganic phosphorus were significantly elevated in rats implanted with MPTCP ceramics. Alkaline phosphatase values in plasma in the experimental group were equal to those in the control group. Photomicrographs, radiographs and scanning electron photomicrographs of the rat femurs implanted with MPTCP ceramics demonstrated excellent bone association with implants and growth of some new bone into MPTCP ceramics. In conclusion, MPTCP ceramics are biocompatible and suitable for the reconstruction of bones.

Keywords

magnetic / ceramics / tricalcium phosphate / biocompatibility

References

[1] MattieDR, et al.. Analysis of the biocompatibility of ALCAP ceramics in rat femurs. J Biomed Mater Res, 1988, 22: 1101-1101

[2] KrajewskiA, et al.. Mineralization and calcium fixation with a porous apatitic ceramic material after implantation in the femur rabbits. J Biomed Mater Res, 1988, 22: 445-445

[3] RenooijW, et al.. Bioresorption of ceramic strontium-85-labeled calcium phosphate implants in dog femurs. Clin Orthop, 1985, 197: 272-272

[4] HollingerJO, et al.. Biodegradable bone repair materials. Clin Orthop, 1986, 207: 290-290

[5] EggliPS, et al.. Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits. Clin Orthop, 1988, 232: 127-127

[6] MetsgerDS, et al.. Tricalcium phosphate ceramics-a resorbable bone implant: review and current status. JADA, 1982, 105: 1035-1035