Influence of cigarette smoking on the hypoxie pulmonary vasoconstriction in isolated rat lungs — The role of prostaglandins and leukotrienes

Abstract

Isolated rat lungs perfused with blood were used to determine the effects of cigarette smoke, delivered into the lung by a ventilator, on the pulmonary vascular resistance (PVR), and on the hypoxic pulmonary vasoconstriction (HPV), and to explore the role the prostsglandines (PG) and leukotrienes (LT) play in. that effect. The results showed that PVR did not change, while HPV was significantly enhanced by smoking. Indomethacin, an inhibitor of PG biosynthesis, administered in the perfusing blood (20 μg/ml) increased HPV in non-smoking lungs, but not in lungs after smoking. Diethylcarbamazine citrate (DEC, l mg/ml),an inhibitor of LT biosynthesis, decreased HPV before and after smoking. After perfusion with both indomethacin and DEC, HPV also decreased. It is suggested that LT act as mediators whereas PG as modulators in HPV, and PG and LT might play an important role in the increase of HPV by cigarette smoking.

References

[1] 1986;9(2): 85

[2] 1989; 1:6

[3] HakinTS, et al.. Effect of chronic cigarette smoke exposure on pulmonary vasomotion in beagle dogs. J Appl Physiol, 1985, 59: 1815-1815

[4] GilmanMJ, et al.. Vascular effects of cigarette smoke in isolated pig lungs. Am Rev Respir Dis, 1981, 124: 549-549

[5] 1989;18(6):428

[6] SachsDP, et al.. Effects of rapid smoking: physiologic evaluation of a smoking-cessation therapy. Am Intern Med, 1978, 88: 639-639

[7] JeremyJY, et al.. Cigarette smoke extracts, but not nicotine, inhibit prostacyclin (PGI₂) synthesis in human, rabbit and rat vascular tissue. Prostaglandins Leukotrienes Med, 1983, 12: 439-439

[8] BusaccaM, et al.. Reduced prostacyclin production by cultured endothelial cells from umbilical arteries of babies born to women who smoke. Lancet, 1982, 2: 609-609

[9] StoelI, et al.. Effect of nicotine on production of prostacyclin in human umbilical artery. Brit Heart J, 1982, 48: 493-493

[10] ToivanenJ, et al.. Effects of smoking and nicotine en human prostacyclin and thromboxane production in vivo and in vitro. Toxicol Appl Pharmacol, 1986, 82: 301-301

[11] LelcukS, et al.. Nicotine stimulates pulmonary parenchymal thromboxanc synthesis. Surgery, 1986, 100: 836-836