Detection of serum hyaluronic acid and laminin in patients with bladder tumors

Abstract

In order to investigate the changes of serum hyaluronic acid (HA) and laminin (LN) levels and their clinical implication in the patients with bladder tumors, the serum HA and LN levels in 34 patients with bladder tumor and 30 cases of control group were detected by radioimmunoassay before and after operation. The results showed that the serum HA and LN levels in the patients with bladder tumors were significantly higher than those in control group (P<0.01) before operation, and decreased significantly after operation (P<0.05). The serum levels of HA and LN in infiltration tumors were higher than those in superficial tumors (P<0.05). The serum HA and LN levels in patients with lymph node metastasis were higher than those without lymph node metastasis (P<0.01). The investigation revealed that HA and LN might be involved in the malignant biology behavior of bladder tumors and could be used as important markers of assistant diagnosis and condition monitoring.

Keywords

bladder tumor / hyaluronic acid / laminin / radioimmunoassay

References

[1] PellegriniR, MartignoneS, TageliabueE, et al.. Prognostic significance of laminin production in relation with its receptor expression in human breast carcinomas. Breast Cancer Res Treat, 1995, 35: 195-195

[2] LiottaL A. Tumor invasion and metastasis-role of the extra cellular matrix: roads memorioal award lecture. Cancer Res, 1986, 46: 1-1

[3] ManleyG, ChristineW. Serum hyaluronic acid in patients with disseminated neoplasm. J Clin Pathol, 1997, 40: 626-626

[4] SkubitzA P, BastR C, WaynerE A, et al.. Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol, 1996, 148(5): 1445-1445

[5] IwahashiM, IkomaM, OtaniT, et al.. Increased serum concentration of type IV collagen and laminin associated with granulosa cell tumor of the ovary. J Clin Pathol, 1997, 50(1): 77-77