The effect of paroxetine on depressive symptom with somatic disease and change of platelet 5-HT concentration

Abstract

To study the effect of paroxetine on depressive symptom accompanying somatic disease and the value of platelet 5-HT concentration in the diagnosis of depression, 30 patients with depressive symptom were treated with paroxetine. All patients were evaluated on Zung and HAMD scale and assayed of platelet 5-HT concentration before and after treatment. It was found that patients had a lower level of platelet 5-HT concentration than healthy people (P<0.01). After six weeks of treatment, depressive and somatic symptoms were both improved (P<0.01) and platelet 5-HT concentration was even lower (P>0.05). It was suggested that paroxetine was a good antidepressant and platelet 5-HT concentration was useful in the screening of depression.

Keywords

paroxetine / depressive symptom / 5-HT

References

[1] NarayanM, AndersonG, CellarJ, et al.. Serotonin transporter blocking properties of nefazodone assessed by measurement of platelet serotonin. J Clin Psychopharmacol, 1998, 18(1): 67-67

[2] BarrL C, GoodmanW K, PriceL H, et al.. The serotonin hypothesis of obsessive-compulsive disorder: Implication of pharmacologic challenge studies. J Clin Psychiatry, 1992, 53(4, suppl): 17-17

[3] VatasseryG T, ScheridanM A, KrezowskiA M, et al.. Spectrophofluorometry of serotonin in blood platelets. Clin Chem, 1981, 27(2): 328-328

[4] SchlakeH P, KahsH, RolfL H, et al.. Platelet 5-HT transport indepressed patients under double-blind treatment with paroxetine versus amitrityline. Acta Psychiatr Scand, 1989, 350: 149-149

[5] ShelineY I, FreedlandK E, CarneyR M, et al.. How safe are serotonin reuptake inhibitors for depression in patients with coronary heart disease?. Am J Med, 1997, 102(1): 54-54

[6] DevaneC L, SalleeF R. Serotonin selective reuptake inhibitors in child and adolescent psychopharmacology: a review of published experience. J Clin Psychiatry, 1996, 57: 55-55

[7] PiccinelliM, Pinis, BellantuonoC, et al.. Efficacy of drug treatment in obsessive-compulsive disorder: a meta-analytic review. Br J Psychiatry, 1995, 166(4): 424-424