Lung DC-T immunity hub in immune surveillance: new concepts and future directions

Juan Liu; Boyi Cong; Xuetao Cao

doi:10.1002/cac2.12643

Cancer Communications ›› 2025, Vol. 45 ›› Issue (3) : 209 -214. DOI: 10.1002/cac2.12643

EDITORIAL

Lung DC-T immunity hub in immune surveillance: new concepts and future directions

Juan Liu ¹
, Boyi Cong ²^,³
, Xuetao Cao ²^,³

Author information +

History +

PDF

Cite this article

Download citation ▾

Juan Liu, Boyi Cong, Xuetao Cao. Lung DC-T immunity hub in immune surveillance: new concepts and future directions. Cancer Communications, 2025, 45(3): 209-214 DOI:10.1002/cac2.12643

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Chen JH, Nieman LT, Spurrell M, Jorgji V, Elmelech L, Richieri P, et al. Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nat Immunol. 2024; 25(4): 644–58.

[2]	Cong B, Dong X, Yang Z, Yu P, Chai Y, Liu J, et al. Single-cell spatiotemporal analysis reveals alveolar dendritic cell-T cell immunity hubs defending against pulmonary infection. Cell Discov. 2024; 10(1): 103.

[3]	Cong B, Dong X, Yang Z, Yu P, Chai Y, Liu J, et al. Single-cell spatiotemporal analysis of the lungs reveals Slamf9(+) macrophages involved in viral clearance and inflammation resolution. Cell Discov. 2024; 10(1): 104.

[4]	Goenka A, Khan F, Verma B, Sinha P, Dmello CC, Jogalekar MP, et al. Tumor microenvironment signaling and therapeutics in cancer progression. Cancer Commun (Lond). 2023; 43(5): 525–61.

[5]	Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021; 184(18): 4734–52 e20.

[6]	Morosi LG, Piperno GM, Lopez L, Amadio R, Joshi S, Rustighi A, et al. ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors. Oncoimmunology. 2024; 13(1): 2367843.

[7]	Magen A, Hamon P, Fiaschi N, Soong BY, Park MD, Mattiuz R, et al. Intratumoral dendritic cell-CD4(+) T helper cell niches enable CD8(+) T cell differentiation following PD-1 blockade in hepatocellular carcinoma. Nat Med. 2023; 29(6): 1389–99.

[8]	Gaglia G, Burger ML, Ritch CC, Rammos D, Dai Y, Crossland GE, et al. Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma. Cancer Cell. 2023; 41(5): 871–86 e10.

[9]	Liu Y, Cao X. Characteristics and Significance of the Pre-metastatic Niche. Cancer Cell. 2016; 30(5): 668–81.

[10]	You S, Li S, Zeng L, Song J, Li Z, Li W, et al. Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity. Cancer Cell. 2024; 42(8): 1415–33 e12.

[11]

Qu X, Wang Y, Jiang Q, Ren T, Guo C, Hua K, et al. Interactions of Indoleamine 2,3-dioxygenase-expressing LAMP3(+) dendritic cells with CD4(+) regulatory T cells and CD8(+) exhausted T cells: synergistically remodeling of the immunosuppressive microenvironment in cervical cancer and therapeutic implications. Cancer Commun (Lond). 2023; 43(11): 1207–28.

[12]	Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020; 20(5): 269–70.

[13]	Narasimhan H, Cheon IS, Qian W, Hu SS, Parimon T, Li C, et al. An aberrant immune-epithelial progenitor niche drives viral lung sequelae. Nature. 2024; 634(8035): 961–9.

[14]	Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020; 580(7802): 257–62.

[15]	Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, et al. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1alpha-Mediated Glycolysis. Immunity. 2019; 50(3): 600–15 e15.

[16]	Zhang X, Chen Y, Sun G, Fei Y, Zhu H, Liu Y, et al. Farnesyl pyrophosphate potentiates dendritic cell migration in autoimmunity through mitochondrial remodelling. Nat Metab. 2024; 6(11): 2118–37.

[17]	Gargaro M, Scalisi G, Manni G, Briseno CG, Bagadia P, Durai V, et al. Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication. Immunity. 2022; 55(6): 1032–50 e14.

[18]	Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023; 620(7972): 200–8.

[19]	Plebanek MP, Xue Y, Nguyen YV, DeVito NC, Wang X, Holtzhausen A, et al. A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. Sci Immunol. 2024; 9(95): eadi4191.

[20]	Nobs SP, Kolodziejczyk AA, Adler L, Horesh N, Botscharnikow C, Herzog E, et al. Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes. Nature. 2023; 624(7992): 645–52.