Two cases of successful treatment of Kaposi's sarcoma by means of extracorporal photochemotherapy are presented in the article. In the first case extracorporal photochemotherapy in the transimmunization regime was performed in patient with immunosuppressive Kaposi's sarcoma and psoriasis, in the second case combined treatment with photopheresis and photodynamic therapy was performed in patient with idiopathic Kaposi's sarcoma.
Authors present a review of treatment methods of lichen ruber planus (LRP) as well as results of a study conducted in clinic dermatovenereology and dermatooncology of Moscow regional scientific and research clinical institute. The effectiveness of combination of tetracycline, Delagil and topical steroids in patients with LRP was assessed. In 52% of patients clinical remission developed, in 42% of cases improvement was noted, and in 6% of patients this treatment had no effect. The treatment was satisfactorily tolerated.
The chronic dermatosis lichen ruber planus (LRP) is discussed, which is rarely developes in military population. Short historical background, classification and clinical presentation of this disease are presented. Several cases of atypical forms of this disease are described.
Bullous pemphigoid - autoimmune bullou dermatosis associated with circulating autoantibodies against antigens of basal membrane of stratified epithelium. Various factors can provoke this bullous dermatosis (ultraviolet radiation, trauma, burns, drugs). Sometimes this disease develop after vaccination against viral or bacterial infection. This paper presents a case of bullous pemphigoid exacerbation as a result of vaccination with influenza virus vaccine in a 72 year old woman. After the treatment improvement was marked and clinical remission of the disease was achieved. This case illustrates the necessity of detailed history analysis concerning manifestation or exacerbation of autoimmune disorders after vaccination.
Description of skin and lung sarcoidosis is presented, including multiple and various skin symptoms and severe rentgenologic and morphologic manifestation in 27 years old resident of Moscow. Skin lesions developed 3,5 years after self-reliant prednisolone withdrawal by patient (prednisolone was prescribed by phthisiatrician for lung sarcoidosis treatment). Skin rush quickly became spread. The patient was treated in in-patient department and received prednisolone (30 mg per os and 30 mg intramuscularly) with subsequent dose decrease. In 3,5 weeks the patient was discharged from hospital. Nodular lesions totally resolved leaving brownish-pink macules.
Authors present literature review and own results concerning recombinant interferone (IFN) use in clinical practice. Therapeutic algorithms for different drug formulations of Viferon (recombinant IFN-α) are presented.
Review of Russian and foreign literature about current treatment methods of circumscribed sclerodermia is presented. Authors examined 82 patients with circumscribed sclerodermia aged 20--75 years old. In all patients oxygen saturation, lesional microcirculation, and proteinogramm were assessed before and after treatment. In a group of patients who underwent complex treatment including infrared irradiation significant improvement of clinical and laboratory parameters was noted.
Authors present a case of severe bullous streptostaphylodermia with separate streptostaphylodermic lesions in 36 y.o. patient. Timely diagnosis and proper treatment allow to control the disease.
The basic literary data on the connection between the symptoms of atopic dermatitis of face and neck with the lipophilic fungi Malassezia are presented in the article. The Malassezia fungi are presented in the atopic dermatitis skin in a greater amount compared with the healthy individuals and can play as superantigens the trigger role in the pathogenesis of atopic dermatitis. Classical local antifungal medicines and some calciumneurine antagonists are shown to be effective in the treatment of atopic dermatitis. The results of the pilot research support this statement.
Authors present a literature review on a chromomycosis and analyze clinical and diagnostic aspects of this rare mycosis. A case of chromomycosis is also presented.
Authors present the results of examination of 50 patients with chronic chlamidyal prostatitis and their treatment with oral enzymes (wobenzym) and antibiotics (vilprafen). Among these patients 23 (46%) were unsuccessfully treated earlier.
Interconnection between the expression of toll-like receptors TLR-2 and TLR-4 on the epithelial surfaces of urogenital tract and clinical signs of urogenital Chlamidia infection in women is presented in the article. Clinicolaboraatory investigation was performed in 41 patients with acute Chlamidia infection, in 29 patients with chronic Chlamidia infection, in 30 patients with the chlamidiosis in anamnesis (markers of the infection were not detected during 1 year by any diagnostic approach) in 32 healthy women (control group). TLR-2 and TLR-4 level can be the criteria for the evaluation of Chlamidia infection and presence of the inflammatory process. In some cases when the pathogenic organism is not detected by laboratory approaches and the diagnosis was stated according to the markers which show indirectly the presence of Chlamidia infection, changes in TLR-2 and TLR-4 levels indicate the irradication of the pathogen. Activation of TLR-2 and TLR-4 is always seen when the strengthening of the protective reactions in the lesion focus happens. Low TLR-2 and TLR-4 levels can indicate the beginning of chronic inflectional process.
We observed 60 (100%) men with myco- and/or ureaplasma infection during 2000--2010. We analyzed clinico-sociological peculiarities of patients and characteristics of urethral microbiota in men with urogenital infection associated with Mycoplasma hominis, Ureaplasma urealyticum, which in most cases was combined.