Expression intensity of TLR-2 and TLR-4 as a criterion of recovery and prognosis in urogenital chlamidiosis
A L Bayrakova , E A Voropaeva , V A Aleshkin , S S Afanas'ev , L I Kafarskaya , Yu V Nesvizhskiy , B A Efimov , A N Shkoporov , O G Grechishnikova , S A Levakov , V A Metel'skaya , M S Afanas'ev , E A Egorova , V V Slobodenyuk , E V Fandeeva , A V Karaulov , S V Suchkov , A L Bayrakova , Е А Voroparva , V А Aleshkin , S S Afanasiev , L I Kafarskaya , Y V Nesvizhsky , B A Efimov , А N Shkoporov , О G Grechishnikova , S А Levakov , V А Metelskaya , М S Afanasiev , Е А Egorova , V V Slobodenyuk , Е V Fandeeva , А V Karaulov , S V Suchkov
Russian Journal of Skin and Venereal Diseases ›› 2011, Vol. 14 ›› Issue (2) : 42 -48.
Expression intensity of TLR-2 and TLR-4 as a criterion of recovery and prognosis in urogenital chlamidiosis
Interconnection between the expression of toll-like receptors TLR-2 and TLR-4 on the epithelial surfaces of urogenital tract and clinical signs of urogenital Chlamidia infection in women is presented in the article. Clinicolaboraatory investigation was performed in 41 patients with acute Chlamidia infection, in 29 patients with chronic Chlamidia infection, in 30 patients with the chlamidiosis in anamnesis (markers of the infection were not detected during 1 year by any diagnostic approach) in 32 healthy women (control group). TLR-2 and TLR-4 level can be the criteria for the evaluation of Chlamidia infection and presence of the inflammatory process. In some cases when the pathogenic organism is not detected by laboratory approaches and the diagnosis was stated according to the markers which show indirectly the presence of Chlamidia infection, changes in TLR-2 and TLR-4 levels indicate the irradication of the pathogen. Activation of TLR-2 and TLR-4 is always seen when the strengthening of the protective reactions in the lesion focus happens. Low TLR-2 and TLR-4 levels can indicate the beginning of chronic inflectional process.
urogenital Chlamidia infection / culture diagnostics / pathogen-associated molecular patterns / toll-like receptors / non-microbal pathogens
| [1] |
Интерфероновый статус, препараты интерферона в лечении и профилактике инфекционных заболеваний и реабилитация больных / Под ред. С. С. Афанасьева и др. - М., 2005. |
| [2] |
Клиника, диагностика и лечение хламидийной инфекции (пособие для врачей) / Кудрявцева Л. В., Мисюрина О. Ю., Генерозов Э. В. и др. - М., 2001. |
| [3] |
О совершенствовании контроля за заболеваниями, передаваемыми половым путем: Метод. рекомендации. - М., 1995. |
| [4] |
Савичева А. М., Башмакова М. А. Урогенитальный хламидиоз у женщин и его последствия. - Н. Новгород, 1998. |
| [5] |
Сидоренко М. Г. Статистика: Учебное пособие. - М., 2007. |
| [6] |
Хламидийная инфекция в акушерстве и гинекологи (Диагностика, клиника, лечение): Метод. пособие / Савичева А. М., Башмакова М. А., Кошелева Н. Г. и др. - СПб., 2002. |
| [7] |
Юнкеров В. И., Григорьев С. Г. Математико-статистическая обработка данных медицинских исследований. 2-е изд. - СПб., 2005. |
| [8] |
Якубович А. И., Корепанов А. Р. Урогенитальный хламидиоз. - Иркутск, 2007. |
| [9] |
Beatty W. L., Morrison R. P., Byrne G. L. // Infect. and Immun. - 1995. - Vol. 63. - P. 199-205. |
| [10] |
Beatty W. L., Byrne G. J., Morrison R. P. // Trends Microbiol. - l994. - Vol. 2. - P. 94-98. |
| [11] |
Darville T., O'Neill J. M., Andrews C. W. et al. // J. Immunol. - 2003. - Vol. 171. - P. 6187-6197. |
| [12] |
Medzhitov R., Preston-Hurlburt P., Janeway C. A. // Nature. - 1997. - P. 388-394. |
| [13] |
Pioli P. A., Amiel E., Schaefer T. M. et al. // Infect. and Immun. - 2004. - Vol. 72. - P. 5799-5806. |
| [14] |
Rock F. L., Hardiman G., Timans J. C. et al. // Proc. Natl. Acad. Sci. USA. - 1998. - Vol. 95. - P. 588. |
| [15] |
Sandor F., Buc M. // Folia Biol. (Praha). - 2005. - Vol. 51. - P. 198-203. |
| [16] |
Shiraki R., Inoue N., Kawasaki S. et al. // Thromb. Res. - 2004. - Vol. 113. - P. 379-385. |
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