Frontiers of Medicine

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2019, Vol.13  No.4

Fecal bacterial culture is a routine clinical examination. Hu et al. found that Candida in stool specimens significantly increased the risk of mortality and was associated with poor prognosis in patients who received haplo-HSCT. (Courtesy of Dr. Xiaodong Mo. See pages 492?503 by Lijuan Hu et al. for more information.)

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2019, Vol.13  No.3

Histone-based malignant transformation, tumour heterogeneity and selection of aggressive characters. Pro-oncogenic events could lead to aberrant activation of silenced histone variants-encoding genes or histone assembly defects or histone under-dosage, leading to increased chromatin dynamics and enhanced genome reprogramming by oncogenic factors. The resulting heterogeneity would create a window of opportunity for the selection of newly reprogrammed oncogenic cells capable of surviving and disseminating. (Courtesy of Dr. Saadi Khochbin. See pages 289-297 by Tao Wang et al. for more information.)

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2019, Vol.13  No.2

The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. (Courtesy of Dr. Xiaojun Huang. See pages 238-249 by Xiaodong Mo et al. for more information.)

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2019, Vol.13  No.1

CH12 treatment led to an increase in apoptosis compared with control in HT-29-S492R EGFR xenografts. Apoptotic cells were detected using the TUNEL assay. The apoptotic index was assessed by the ratio of TUNEL-positive cells: total number of cells from six randomly selected high power fields in xenografts from six mice of each group. (Courtesy of Dr. Hua Jiang. See pages 83-93 by Qiongna Dong et al. for more information.)

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2018, Vol.12  No.6

Proposed design mechanism of platelet membrane-based drug delivery systems and nanoparticle-based platelets inhibition for cancer therapy. (A) Natural or genetically engineered platelet membrane-based drug loading. (B) The blockage of cancer cells and platelets interaction by nanoparticle could realize tumor inhibition. (Courtesy of Drs. Jingyan Wei and Guangjun Nie. See pages 667-677 by Yinlong Zhang et al. for more information.)

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2018, Vol.12  No.5

Placental arteries were immunohistochemically assessed (400×). Blue spots represent nuclei. Arrows indicate antibody stain. HSP20 (left) and pHSP20 (right) were located in the cytoplasm and on the cell surface of smooth muscle. (Courtesy of Dr. Dongrui Deng. See pages 542-549 by Fanfan Li et al. for more information.)

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2018, Vol.12  No.4

TME components that regulate tumor progression. Schematic illustration of the major cellular and non-cellular components of TME that either promote (pink arrows) or inhibit (green “T” shapes) tumor progression. (Courtesy of Dr. Yibin Kang. See pages 426-439 by Minhong Shen and Yibin Kang for more information.)

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2018, Vol.12  No.3

Intraoperative views of keel placement.  The keel was kept in place to separate raw laryngeal surfaces. (Courtesy of Dr. Lei Cheng and Haitao Wu. See pages 301-306 by Jian Chen et al. for more information.)

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2018, Vol.12  No.2

Lung transplantation is a treatment option for patients with end-stage BOS after HSCT. (A, B) One patient underwent bone marrow transplant for ALL in 2003 and he received BLT due to severe BOS in 2012. Since then, he has been leading a normal, active life. (C, D) Another patient suffered from BOS two years after HSCT, and she underwent BLT in 2014. Pulmonary function improved significantly after the transplant, and maintained normal during the follow-up. (Courtesy of Dr. Jingyu Chen. See pages 224-228 by Fei Gao et al. for more information.)

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2018, Vol.12  No.1

Shanghai Public Health Clinical Center (SPHCC) affiliated to Fudan University is a Class A tertiary hospital, formerly known as Shanghai Infectious Diseases Hospital. SPHCC’s predecessor was Chinese Isolation Hospital which was founded in 1914. Over the past hundred years, SPHCC has made great contributions to the management and research of infectious diseases and excellent achievements in fighting against HAV, acute gastroenteritis, SARS, H1N1, H7N9, HIV, etc. (Courtesy of Shanghai Public Health Clinical Center.)

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2017, Vol.11  No.4

Chronic HIV-1 infection leads to irreversible B cell perturbations despite of effective combined antiretroviral therapy (cART). Moreover, the recall antigen responses are persistently imparied even after cART. (Courtesy of Dr. Jingjing Yan. See pages 536-547 by Jingjing Yan et al. for more information.)

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