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Frontiers of Medicine

Front. Med.    2020, Vol. 14 Issue (2) : 126-135
Coronavirus disease 2019 (COVID-19): a clinical update
Min Zhou1,2,3, Xinxin Zhang1,4, Jieming Qu1,2,3()
1. National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2. Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
4. Research Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

Keywords coronavirus disease 2019      epidemiology      pathology      radiology      clinical characteristics      treatment     
Corresponding Authors: Jieming Qu   
Just Accepted Date: 13 March 2020   Online First Date: 02 April 2020    Issue Date: 09 May 2020
 Cite this article:   
Min Zhou,Xinxin Zhang,Jieming Qu. Coronavirus disease 2019 (COVID-19): a clinical update[J]. Front. Med., 2020, 14(2): 126-135.
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Fig.1  Chest CT of COVID-19 patients with different severity. (A) A 57-year-old man with mild COVID-19 showed unilateral and slight GGO. (B) A 52-year-old male patient classified into moderate type exhibited multifocal and bilateral GGO with sub-pleural distribution. (C) In a 26-year-old man with severe COVID-19, bilateral and multifocal lesions were observed with a combination of pure GGO, mixed GGO, and consolidation. (D) In a 50-year-old critically ill women, chest CT showed bilateral massive shadows of high density and GGO, accompanied by air bronchogram sign.
1 Z Wu, JM McGoogan. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020 Feb 24. [Epub ahead of print] doi: 10.1001/jama.2020.2648 pmid: 32091533
2 Q Li, X Guan, P Wu, X Wang, L Zhou, Y Tong, R Ren, KSM Leung, EHY Lau, JY Wong, X Xing, N Xiang, Y Wu, C Li, Q Chen, D Li, T Liu, J Zhao, M Liu, W Tu, C Chen, L Jin, R Yang, Q Wang, S Zhou, R Wang, H Liu, Y Luo, Y Liu, G Shao, H Li, Z Tao, Y Yang, Z Deng, B Liu, Z Ma, Y Zhang, G Shi, TTY Lam, JTK Wu, GF Gao, BJ Cowling, B Yang, GM Leung, Z Feng. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020 Jan 29. [Epub ahead of print] doi: 10.1056/NEJMoa2001316 pmid: 31995857
3 H Wang, Z Wang, Y Dong, R Chang, C Xu, X Yu, S Zhang, L Tsamlag, M Shang, J Huang, Y Wang, G Xu, T Shen, X Zhang, Y Cai. Phase-adjusted estimation of the number of coronavirus disease 2019 cases in Wuhan, China. Cell Discov 2020; 6(1): 10 pmid: 32133152
4 N Chen, M Zhou, X Dong, J Qu, F Gong, Y Han, Y Qiu, J Wang, Y Liu, Y Wei, J Xia, T Yu, X Zhang, L Zhang. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395(10223): 507–513 pmid: 32007143
5 JF Chan, S Yuan, KH Kok, KK To, H Chu, J Yang, F Xing, J Liu, CC Yip, RW Poon, HW Tsoi, SK Lo, KH Chan, VK Poon, WM Chan, JD Ip, JP Cai, VC Cheng, H Chen, CK Hui, KY Yuen. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395(10223): 514–523 pmid: 31986261
6 R Huang, J Xia, Y Chen, C Shan, C Wu. A family cluster of SARS-CoV-2 infection involving 11 patients in Nanjing, China. Lancet Infect Dis 2020 Feb 28. [Epub ahead of print] doi: 10.1016/S1473-3099(20)30147-X pmid: 32119823
7 W Zhang, RH Du, B Li, XS Zheng, XL Yang, B Hu, YY Wang, GF Xiao, B Yan, ZL Shi, P Zhou. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect 2020; 9(1): 386–389 pmid: 32065057
8 SWX Ong, YK Tan, PY Chia, TH Lee, OT Ng, MSY Wong, K Marimuthu. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA 2020 Mar 4. [Epub ahead of print] doi: 10.1001/jama.2020.3227 pmid: 32129805
9 N Zhu, D Zhang, W Wang, X Li, B Yang, J Song, X Zhao, B Huang, W Shi, R Lu, P Niu, F Zhan, X Ma, D Wang, W Xu, G Wu, GF Gao, W Tan; China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727–733 pmid: 31978945
10 S Su, G Wong, W Shi, J Liu, ACK Lai, J Zhou, W Liu, Y Bi, GF Gao. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 2016; 24(6): 490–502 pmid: 27012512
11 D Forni, R Cagliani, M Clerici, M Sironi. Molecular evolution of human coronavirus genomes. Trends Microbiol 2017; 25(1): 35–48 pmid: 27743750
12 R Lu, X Zhao, J Li, P Niu, B Yang, H Wu, W Wang, H Song, B Huang, N Zhu, Y Bi, X Ma, F Zhan, L Wang, T Hu, H Zhou, Z Hu, W Zhou, L Zhao, J Chen, Y Meng, J Wang, Y Lin, J Yuan, Z Xie, J Ma, WJ Liu, D Wang, W Xu, EC Holmes, GF Gao, G Wu, W Chen, W Shi, W Tan. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395(10224): 565–574 pmid: 32007145
13 D Wrapp, N Wang, KS Corbett, JA Goldsmith, CL Hsieh, O Abiona, BS Graham, JS McLellan. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020 Feb 19. [Epub ahead of print] doi: 10.1126/science.abb2507 pmid: 32075877
14 X Xu, P Chen, J Wang, J Feng, H Zhou, X Li, W Zhong, P Hao. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci 2020; 63(3): 457–460 pmid: 32009228
15 P Zhou, XL Yang, XG Wang, B Hu, L Zhang, W Zhang, HR Si, Y Zhu, B Li, CL Huang, HD Chen, J Chen, Y Luo, H Guo, RD Jiang, MQ Liu, Y Chen, XR Shen, X Wang, XS Zheng, K Zhao, QJ Chen, F Deng, LL Liu, B Yan, FX Zhan, YY Wang, GF Xiao, ZL Shi. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270–273
16 E de Wit, N van Doremalen, D Falzarano, VJ Munster. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol 2016; 14(8): 523–534 pmid: 27344959
17 National Health Commission of the People’s Republic of China. Guideline for the diagnosis and treatment of COVID-19 infections (version 1–7). 2020.
18 XW Xu, XX Wu, XG Jiang, KJ Xu, LJ Ying, CL Ma, SB Li, HY Wang, S Zhang, HN Gao, JF Sheng, HL Cai, YQ Qiu, LJ Li. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ 2020; 368: m606 pmid: 32075786
19 JJ Zhang, X Dong, YY Cao, YD Yuan, YB Yang, YQ Yan, CA Akdis, YD Gao. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy 2020 Feb 19. [Epub ahead of print] doi: 10.1111/all.14238 pmid: 32077115
20 X Yang, Y Yu, J Xu, H Shu, J Xia, H Liu, Y Wu, L Zhang, Z Yu, M Fang, T Yu, Y Wang, S Pan, X Zou, S Yuan, Y Shang. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020 Feb 24. [Epub ahead of print] doi: 10.1016/S2213-2600(20)30079-5 pmid: 32105632
21 WJ Guan, ZY Ni, Y Hu, WH Liang, CQ Ou, JX He, L Liu, H Shan, CL Lei, DSC Hui, B Du, LJ Li, G Zeng, KY Yuen, RC Chen, CL Tang, T Wang, PY Chen, J Xiang, SY Li, JL Wang, ZJ Liang, YX Peng, L Wei, Y Liu, YH Hu, P Peng, JM Wang, JY Liu, Z Chen, G Li, ZJ Zheng, SQ Qiu, J Luo, CJ Ye, SY Zhu, NS Zhong; China Medical Treatment Expert Group for COVID-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020 Feb 28. [Epub ahead of print] doi: 10.1056/NEJMoa2002032 pmid: 32109013
22 C Huang, Y Wang, X Li, L Ren, J Zhao, Y Hu, L Zhang, G Fan, J Xu, X Gu, Z Cheng, T Yu, J Xia, Y Wei, W Wu, X Xie, W Yin, H Li, M Liu, Y Xiao, H Gao, L Guo, J Xie, G Wang, R Jiang, Z Gao, Q Jin, J Wang, B Cao. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497–506 pmid: 31986264
23 D Wang, B Hu, C Hu, F Zhu, X Liu, J Zhang, B Wang, H Xiang, Z Cheng, Y Xiong, Y Zhao, Y Li, X Wang, Z Peng. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020 Feb 7. [Epub ahead of print] doi: 10.1001/jama.2020.1585 pmid: 32031570
24 WHO. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. 2020.
25 SV Konstantinides, G Meyer, C Becattini, H Bueno, GJ Geersing, VP Harjola, MV Huisman, M Humbert, CS Jennings, D Jiménez, N Kucher, IM Lang, M Lankeit, R Lorusso, L Mazzolai, N Meneveau, F Ní Áinle, P Prandoni, P Pruszczyk, M Righini, A Torbicki, E Van Belle, JL Zamorano; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2020; 41(4): 543–603 pmid: 31504429
26 S Tian, W Hu, L Niu, H Liu, H Xu, SY Xiao. Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol 2020 Feb 27. [Epub ahead of print] doi: 10.1016/j.jtho.2020.02.010 pmid: 32114094
27 Z Xu, L Shi, Y Wang, J Zhang, L Huang, C Zhang, S Liu, P Zhao, H Liu, L Zhu, Y Tai, C Bai, T Gao, J Song, P Xia, J Dong, J Zhao, FS Wang. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020 Feb 18. [Epub ahead of print] doi: 10.1016/S2213-2600(20)30076-X. pmid: 32085846
28 W, Luo H, Yu J, Gou X, Li Y, Sun J, Li L. LiuClinical pathology of critical patient with novel coronavirus pneumonia (COVID-19). Preprints 2020; 2020020407
29 H Shi, X Han, N Jiang, Y Cao, O Alwalid, J Gu, Y Fan, C Zheng. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis 2020 Feb 24. [Epub ahead of print] doi: 10.1016/S1473-3099(20)30086-4 pmid: 32105637
30 W Zhao, Z Zhong, X Xie, Q Yu, J Liu. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicenter study. AJR Am J Roentgenol 2020 Mar 3. [Epub ahead of print] doi: 10.2214/AJR.20.22976 pmid: 32125873
31 HJ Koo, S Lim, J Choe, SH Choi, H Sung, KH Do. Radiographic and CT features of viral pneumonia. Radiographics 2018; 38(3): 719–739 pmid: 29757717
32 T Franquet, NL Müller, A Giménez, S Martínez, M Madrid, P Domingo. Infectious pulmonary nodules in immunocompromised patients: usefulness of computed tomography in predicting their etiology. J Comput Assist Tomogr 2003; 27(4): 461–468 pmid: 12886125
33 X Xu, C Yu, J Qu, L Zhang, S Jiang, D Huang, B Chen, Z Zhang, W Guan, Z Ling, R Jiang, T Hu, Y Ding, L Lin, Q Gan, L Luo, X Tang, J Liu. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Eur J Nucl Med Mol Imaging 2020 Feb 28. [Epub ahead of print] doi: 10.1007/s00259-020-04735-9 pmid: 32107577
34 J Wu, CL Feng, XY Xian, J Qiang, J Zhang, QX Mao, SF Kong, YC Chen, JP Pan. Novel coronavirus pneumonia (COVID-19) CT distribution and sign features. Chin J Tuberc Respir Dis (Zhonghua Jie He He Hu Xi Za Zhi) 2020 Mar 3. [Epub ahead of print] (in Chinese) doi: 10.3760/cma.j.cn112147-20200217-00106 pmid: 32125131
35 D Falzarano, E de Wit, C Martellaro, J Callison, VJ Munster, H Feldmann. Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin. Sci Rep 2013; 3(1): 1686 pmid: 23594967
36 H Momattin, AY Al-Ali, JA Al-Tawfiq. A Systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV). Travel Med Infect Dis 2019; 30: 9–18 pmid: 31252170
37 Y Shi. What are the highlights of “Diagnosis and treatment of Disease 2019 novel coronavirus infection suitable for Military support Hubei medical team”. Chin J Tuberc Respir Dis (Zhonghua Jie He He Hu Xi Za Zhi) 2020 Feb 26. [Epub ahead of print] (in Chinese) doi: 10.3760/cma.j.cn112147-20200225-00183 pmid: 32098466
38 M Wang, R Cao, L Zhang, X Yang, J Liu, M Xu, Z Shi, Z Hu, W Zhong, G Xiao. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020; 30(3): 269–271 pmid: 32020029
39 TP Sheahan, AC Sims, RL Graham, VD Menachery, LE Gralinski, JB Case, SR Leist, K Pyrc, JY Feng, I Trantcheva, R Bannister, Y Park, D Babusis, MO Clarke, RL Mackman, JE Spahn, CA Palmiotti, D Siegel, AS Ray, T Cihlar, R Jordan, MR Denison, RS Baric. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 2017; 9(396): eaal3653 pmid: 28659436
40 E de Wit, F Feldmann, J Cronin, R Jordan, A Okumura, T Thomas, D Scott, T Cihlar, H Feldmann. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proc Natl Acad Sci USA 2020 Feb 13. [Epub ahead of print] doi: 10.1073/pnas.1922083117 pmid: 32054787
41 EJ Chow, JD Doyle, TM Uyeki. Influenza virus-related critical illness: prevention, diagnosis, treatment. Crit Care 2019; 23(1): 214 pmid: 31189475
42 Y Shi, Y Huang, TT Zhang, B Cao, H Wang, C Zhuo, F Ye, X Su, H Fan, JF Xu, J Zhang, GX Lai, DY She, XY Zhang, B He, LX He, YN Liu, JM Qu. Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition). J Thorac Dis 2019; 11(6): 2581–2616 pmid: 31372297
43 O Nishida, H Ogura, M Egi, S Fujishima, Y Hayashi, T Iba, H Imaizumi, S Inoue, Y Kakihana, J Kotani, S Kushimoto, Y Masuda, N Matsuda, A Matsushima, TA Nakada, S Nakagawa, S Nunomiya, T Sadahiro, N Shime, T Yatabe, Y Hara, K Hayashida, Y Kondo, Y Sumi, H Yasuda, K Aoyama, T Azuhata, K Doi, M Doi, N Fujimura, R Fuke, T Fukuda, K Goto, R Hasegawa, S Hashimoto, J Hatakeyama, M Hayakawa, T Hifumi, N Higashibeppu, K Hirai, T Hirose, K Ide, Y Kaizuka, T Kan’o, T Kawasaki, H Kuroda, A Matsuda, S Matsumoto, M Nagae, M Onodera, T Ohnuma, K Oshima, N Saito, S Sakamoto, M Sakuraya, M Sasano, N Sato, A Sawamura, K Shimizu, K Shirai, T Takei, M Takeuchi, K Takimoto, T Taniguchi, H Tatsumi, R Tsuruta, N Yama, K Yamakawa, C Yamashita, K Yamashita, T Yoshida, H Tanaka, S Oda. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). Acute Med Surg 2018; 5(1): 3–89 pmid: 29445505
44 HY Lee, CK Rhee, JW Lee. Feasibility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematologic malignancies: a retrospective single-center study. J Crit Care 2015; 30(4): 773–777 pmid: 25840520
45 L Dangers, C Montlahuc, A Kouatchet, S Jaber, F Meziani, S Perbet, T Similowski, M Resche-Rigon, E Azoulay, A Demoule; REVA Network (Research Network in Mechanical Ventilation) and the Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie (GrrrOH); List of contributors who included study patients: Angers University Hospital, Angers, France. Dyspnoea in patients receiving noninvasive ventilation for acute respiratory failure: prevalence, risk factors and prognostic impact: a prospective observational study. Eur Respir J 2018; 52(2): 1702637 pmid: 29976650
46 E Fan, L Del Sorbo, EC Goligher, CL Hodgson, L Munshi, AJ Walkey, NKJ Adhikari, MBP Amato, R Branson, RG Brower, ND Ferguson, O Gajic, L Gattinoni, D Hess, J Mancebo, MO Meade, DF McAuley, A Pesenti, VM Ranieri, GD Rubenfeld, E Rubin, M Seckel, AS Slutsky, D Talmor, BT Thompson, H Wunsch, E Uleryk, J Brozek, LJ Brochard; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine. An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2017; 195(9): 1253–1263 pmid: 28459336
47 E Fan, D Brodie, AS Slutsky. Diagnosis and treatment in acute respiratory distress syndrome-reply. JAMA 2018; 320(3): 306 pmid: 30027245
48 HH Yang, Y Zhou. Effect of invasive and non-invasive positive pressure ventilation on plasma brain natriuretic peptide in patients with chronic obstructive pulmonary disease and severe respiratory failure. J South Med Univ (Nan Fang Yi Ke Da Xue Xue Bao) 2010; 30(10): 2377–2379 (in Chinese)
pmid: 20965851
49 DS Hui. Severe acute respiratory syndrome (SARS): lessons learnt in Hong Kong. J Thorac Dis 2013; 5(Suppl 2): S122–S126
pmid: 23977432
50 C Ronco, P Navalesi, JL Vincent. Coronavirus epidemic: preparing for extracorporeal organ support in intensive care. Lancet Respir Med 2020; 8(3): 240–241 pmid: 32035509
51 Y Cheng, R Luo, K Wang, M Zhang, Z Wang, L Dong, J Li, Y Yao, Xu G Ge S,. Kidney impairment is associated with in-hospital death of COVID-19 patients. Medrxiv 2020; doi: 10.1101/2020.02.18.20023242
52 K Träger, C Schütz, G Fischer, J Schröder, C Skrabal, A Liebold, H Reinelt. Cytokine reduction in the setting of an ARDS-associated inflammatory response with multiple organ failure. Case Rep Crit Care 2016; 2016: 9852073 pmid: 26885411
53 J Mair-Jenkins, M Saavedra-Campos, JK Baillie, P Cleary, FM Khaw, WS Lim, S Makki, KD Rooney, JS Nguyen-Van-Tam, CR Beck; Convalescent Plasma Study Group. The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis. J Infect Dis 2015; 211(1): 80–90 pmid: 25030060
54 LJ Stockman, R Bellamy, P Garner. SARS: systematic review of treatment effects. PLoS Med 2006; 3(9): e343 pmid: 16968120
55 S Mustafa, H Balkhy, MN Gabere. Current treatment options and the role of peptides as potential therapeutic components for Middle East respiratory syndrome (MERS): a review. J Infect Public Health 2018; 11(1): 9–17 pmid: 28864360
56 PI Lee, PR Hsueh. Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV. J Microbiol Immunol Infect 2020 Feb 4. [Epub ahead of print] doi: 10.1016/j.jmii.2020.02.001 pmid: 32035811
57 L Chen, J Xiong, L Bao, Y Shi. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis 2020 Feb 27. [Epub ahead of print] doi: 10.1016/S1473-3099(20)30141-9 pmid: 32113510
58 Y Kaneko, M Kato, Y Tanaka, M Inoo, H Kobayashi-Haraoka, K Amano, M Miyata, Y Murakawa, H Yasuoka, S Hirata, E Tanaka, N Miyasaka, H Yamanaka, K Yamamoto, T Takeuchi; SURPRISE study group. Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study). Ann Rheum Dis 2018; 77(9): 1268–1275 pmid: 29853455
59 Y Kaneko, H Kameda, K Ikeda, T Ishii, K Murakami, H Takamatsu, Y Tanaka, T Abe, T Takeuchi. Tocilizumab in patients with adult-onset still’s disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial. Ann Rheum Dis 2018; 77(12): 1720–1729 pmid: 30279267
60 JH Stone, K Tuckwell, S Dimonaco, M Klearman, M Aringer, D Blockmans, E Brouwer, MC Cid, B Dasgupta, J Rech, C Salvarani, G Schett, H Schulze-Koops, R Spiera, SH Unizony, N Collinson. Trial of tocilizumab in giant-cell arteritis. N Engl J Med 2017; 377(4): 317–328 pmid: 28745999
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