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Frontiers of Medicine

Front. Med.    2020, Vol. 14 Issue (2) : 126-135     https://doi.org/10.1007/s11684-020-0767-8
REVIEW
Coronavirus disease 2019 (COVID-19): a clinical update
Min Zhou1,2,3, Xinxin Zhang1,4, Jieming Qu1,2,3()
1. National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2. Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
4. Research Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

Keywords coronavirus disease 2019      epidemiology      pathology      radiology      clinical characteristics      treatment     
Corresponding Authors: Jieming Qu   
Just Accepted Date: 13 March 2020   Online First Date: 02 April 2020    Issue Date: 09 May 2020
 Cite this article:   
Min Zhou,Xinxin Zhang,Jieming Qu. Coronavirus disease 2019 (COVID-19): a clinical update[J]. Front. Med., 2020, 14(2): 126-135.
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http://journal.hep.com.cn/fmd/EN/Y2020/V14/I2/126
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Fig.1  Chest CT of COVID-19 patients with different severity. (A) A 57-year-old man with mild COVID-19 showed unilateral and slight GGO. (B) A 52-year-old male patient classified into moderate type exhibited multifocal and bilateral GGO with sub-pleural distribution. (C) In a 26-year-old man with severe COVID-19, bilateral and multifocal lesions were observed with a combination of pure GGO, mixed GGO, and consolidation. (D) In a 50-year-old critically ill women, chest CT showed bilateral massive shadows of high density and GGO, accompanied by air bronchogram sign.
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