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Frontiers of Medicine

Front. Med.    2020, Vol. 14 Issue (2) : 210-214     https://doi.org/10.1007/s11684-020-0757-x
CASE REPORT
Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19
Li Ni1, Ling Zhou1, Min Zhou2, Jianping Zhao2, Dao Wen Wang1()
1. Division of Cardiology;
2. Division of Respiration, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract

In December 2019, an outbreak of novel coronavirus (2019-nCoV) occurred in Wuhan, Hubei Province, China. By February 14, 2020, it has led to 66 492 confirmed patients in China and high mortality up to ~2.96% (1123/37 914) in Wuhan. Here we report the first family case of coronavirus disease 2019 (COVID-19) confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid (SHL). This report describes the identification, diagnosis, clinical course, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19, and warrants further clinical trials.

Keywords novel coronavirus (2019-nCoV)      COVID-19      Chinese traditional patent medicine      Shuanghuanglian oral liquid     
Corresponding Author(s): Dao Wen Wang   
Just Accepted Date: 19 February 2020   Online First Date: 16 March 2020    Issue Date: 09 May 2020
 Cite this article:   
Li Ni,Ling Zhou,Min Zhou, et al. Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19[J]. Front. Med., 2020, 14(2): 210-214.
 URL:  
http://journal.hep.com.cn/fmd/EN/10.1007/s11684-020-0757-x
http://journal.hep.com.cn/fmd/EN/Y2020/V14/I2/210
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Li Ni
Ling Zhou
Min Zhou
Jianping Zhao
Dao Wen Wang
Fig.1  Chest CT images of case 1. (A) CT imaging on January 23, 2020 shows ground glass opacity in both lungs on illness day 7. (B) Image taken on January 28, 2020, shows aggravation of pneumonia on illness day 12. (C) Image taken on February 6, 2020 shows the absorption of bilateral ground glass opacity after SHL treatment from January 28.
Specimen Case 1 Case 2 Case 3
Illness day 12 Illness day 20 Illness day 23 Illness day 3 Illness day 11 Illness day 14 Illness day 3 Illness day 11
Nasopharyngeal swab Negative Negative NT Negative Negative NT Positive Negative
Anal swab NT NT Negative NT NT Negative NT NT
Tab.1  Testing results of 2019-nCoV
Fig.2  Symptoms, maximum body temperatures, and treatment timeline in accordance with day of illness and day of hospitalization (January 17 to February 10).
Measure Reference range Illness day 13 Illness day 24
Hospital day 2 Hospital day 13
White cell count (×109/L) 3.50–9.50 5.93 5.46
Red cell count (×109/L) 3.80–5.10 4.13 4.06
Neutrophil count (×109/L) 1.90–6.30 3.04 3.27
Lymphocyte count (×109/L) 1.10–3.20 2.11 1.5
Eosinophil count (×109/L) 0.02–0.52 0.12 0.15
Platelet count (×109/L) 125.0–350.0 361 323
Hemoglobin (g/L) 115.0–150.0 113 111
Hematocrit (%) 35.0–45.0 35 35
Sodium (mmol/L) 136–214 140 140.4
Potassium (mmol/L) 3.50–5.10 4.22 4.8
Chloride (mmol/L) 99–110 104.6 102.4
Calcium (mmol/L) 2.15–2.50 2.06 ↓ 2.19
Carbon dioxide (mmol/L) 22.0–29.0 21 ↓ 25.1
Glucose (mmol/L) 4.11–6.05 5.01
Blood urea nitrogen (mmol/L) 2.6–7.5 3.1 3.6
Creatinine (mmol/L) 45–84 53 60
Total protein (g/L) 64–83 68.4 68.6
Albumin (g/L) 35–52 29.6 ↓ 33.2 ↓
Total bilirubin (mmol/L) ≤21 6.4 4.5
Procalcitonin (ng/mL) ≤0.05 0.03 0.03
Alanine aminotransferase (U/L) ≤33 17 20
Aspartate aminotransferase (U/L) ≤32 16 19
Alkaline phosphatase (U/L) 35–105 59 83
Fibrinogen (g/L) 2.00–4.00 5.31 ↑
Lactate dehydrogenase (U/L) 135–214 248 ↑
Prothrombin time (s) 11.5–14.5 13.6
International normalized ratio 0.80–1.20 1.03
Creatine kinase (U/L) ≤170 35 27
C-reactive protein (mg/L) ≤3 57.8 ↑
Tab.2  Clinical laboratory results of case 1
Fig.3  Chest CT images of case 2. (A) CT imaging obtained from case 2 on January 28, 2020 shows consolidation shadow in the left lung on illness day 3. (B) Image taken on February 6, 2020 shows the absorption of consolidation shadow after SHL treatment from January 28.
Measure Reference range Illness day 4 Illness day 15
Hospital day 2 Hospital day 13
White cell count (×109/L) 3.50–9.50 3.63 5.79
Red cell count (×109/L) 3.80–5.10 4.5 4.28
Neutrophil count (×109/L) 1.90–6.30 2.12 3.2
Lymphocyte count (×109/L) 1.10–3.20 1.25 1.98
Eosinophil count (×109/L) 0.02–0.52 0.01 0.17
Platelet count (×109/L) 125.0–350.0 139 308
Hemoglobin (g/L) 115.0–150.0 125 117
Hematocrit (%) 35.0–45.0 37.9 36.2
Sodium (mmol/L) 136–214 135.3 143.5
Potassium (mmol/L) 3.50–5.10 3.69 4.27
Chloride (mmol/ L) 99–110 97 ↓ 106.3
Calcium (mmol/L) 2.15–2.50 2.25 2.27
Carbon dioxide (mmol/L) 22.0–29.0 22.3 25.2
Glucose (mmol/L) 4.11–6.05 4.31 4.82
Blood urea nitrogen (mmol/L) 2.6–7.5 2.7 3.4
Creatinine (mmol/L) 45–84 59 52
Total protein (g L) 64–83 77.2 65.6
Albumin (g/L) 35–52 41.5 37.5
Total bilirubin (mmol/L) ≤21 6.6 4
Procalcitonin (ng/mL) ≤0.05 0.04
Alanine aminotransferase (U/L) ≤33 8 50 ↑
Aspartate aminotransferase (U/L) ≤32 21 27
Alkaline phosphatase (U/L) 35–105 52 22 ↓
Fibrinogen (g/L) 2.00–4.00 3.42
Lactate dehydrogenase (U/L) 135–214 170 186
Prothrombin time (s) 11.5–14.5 13.6
International normalized ratio 0.80–1.20 1.03
Creatine kinase (U/L) ≤170 52 27
C-reactive protein (mg/L) ≤3 9.4 ↑
Tab.3  Clinical laboratory results of case 2
Fig.4  Chest CT images of case 3. (A) CT imaging obtained from case 3 on January 28, 2020 shows ground glass opacity in the left lung on illness day 3. (B) Image taken on February 7, 2020 shows the absorption of ground glass opacity after SHL treatment from January 28.
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