Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Front. Med. ›› 2007, Vol. 1 ›› Issue (2) : 200 -206.

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Front. Med. ›› 2007, Vol. 1 ›› Issue (2) :200 -206. DOI: 10.1007/s11684-007-0038-y
Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance
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Abstract

Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2 diabetes mellitus. In this study, we investigated the effects of two fatty acids, palmitate (PA) and arach

Keywords

insulin resistance / palmitate / protein kinase B / glycogen synthase / arachidonic acid

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XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing. Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance. Front. Med., 2007, 1(2): 200-206 DOI:10.1007/s11684-007-0038-y

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