Quinoa as a naturally stress-resistant crop: current status and future promises

Abstract

Quinoa (Chenopodium quinoa Willd.), a semi-domesticated halophyte originating in the Andean region, has emerged as a promising crop for exploiting marginal lands, valued for its exceptional nutritional profile and remarkable resilience to high salinity and drought. This review analyzes the current status and future potential of quinoa as a model halophytic crop. We begin by examining the physiological mechanisms that enable quinoa to thrive in marginal environments, which have been the subject of extensive study. Thanks to the advancement in high-throughput sequencing technology, genomic resources – including the recent development of high-quality reference genomes and a Chenopodium pangenome – are rapidly expanding. Sequence-based genetic mapping techniques hold the promise to dissect the molecular basis of complex traits in combination with the utility of functional genomics tools such as virus-induced gene silencing (VIGS) and stable genetic transformation. Ultimately, the application of modern breeding technologies, such as phenomics, genomic selection (GS), and CRISPR/Cas, will expedite the development of locally adapted, climate-resilient quinoa cultivars worldwide.

Keywords

Halophyte / Salinity resistance / Drought resistance / Preharvest sprouting / Heat stress

References

[1] Abbas Get al.. Differential effect of heat stress on drought and salt tolerance potential of quinoa genotypes: a physiological and biochemical investigation Plants (Basel). Plants, 2023, 12: 774

[2] Abdelshafy AM, Rashwan AK, Osman AI. Potential food applications and biological activities of fermented quinoa: A review. Trends Food Sci Tech, 2024, 144: 104339

[3] Adolf VI, Jacobsen SE, Shabala S. Salt tolerance mechanisms in quinoa (Chenopodium quinoa Willd.). Environ Exp Bot, 2013, 92: 43-54

[4] Afzal I, Haq MZU, Ahmed S, Hirich A, Bazile D. Challenges and perspectives for integrating quinoa into the agri-food system. Plants, 2023

[5] Agarie Set al.. Salt tolerance, salt accumulation, and ionic homeostasis in an epidermal bladder-cell-less mutant of the common ice plant Mesembryanthemum crystallinum. J Exp Bot, 2007, 58: 1957-1967

[6] Alandia G, Rodriguez JP, Jacobsen SE, Bazile D, Condori B. Global expansion of quinoa and challenges for the Andean region. Glob Food Secur, 2020

[7] Alshammari AA, Abu-Elsaoud AM, AlShammari W, Abdulmajeed AM, Aysh ALrashidi A, Alghanem SMS, Rudayni H, Al-Zharani M, Alnusaire TS, Soliman MH (2025) Myoinositol enhances heat tolerance in Chenopodium quinoa through integrated physiological, biochemical, and molecular responses. Funct Plant Biol 52(12):FP25281. https://doi.org/10.1071/FP25281

[8] Alvar-Beltrán J, Verdi L, Marta AD, Dao A, Vivoli R, Sanou J, Orlandini S. The effect of heat stress on quinoa (cv. Titicaca) under controlled climatic conditions. J Agr Sci-Cambridge, 2020, 158: 255-261

[9] Alvarez-Flores R, Anh NTT, Peredo-Parada S, Joffre R, Winkel T. Rooting plasticity in wild and cultivated Andean Chenopodium species under soil water deficit. Plant Soil, 2018, 425: 479-492

[10] Bazihizina Net al.. Stalk cell polar ion transport provide for bladder-based salinity tolerance in Chenopodium quinoa. New Phytol, 2022, 235: 1822-1835

[11] Bazile D, Jacobsen SE, Verniau A. The global expansion of quinoa: trends and limits. Front Plant Sci, 2016, 7: 622

[12] Bohm Jet al.. Understanding the molecular basis of salt sequestration in epidermal bladder cells of Chenopodium quinoa. Curr Biol, 2018, 28: 3075-3085 e3077

[13] Burrieza HP, Koyro HW, Tosar LM, Kobayashi K, Maldonado S. High salinity induces dehydrin accumulation in Chenopodium quinoa Willd. cv. Hualhuas embryos. Plant Soil, 2012, 354: 69-79

[14] Cao MJet al.. Combining chemical and genetic approaches to increase drought resistance in plants. Nat Commun, 2017, 8: 1183

[15] Ceccato D, Bertero D, Batlla D, Galati B. Structural aspects of dormancy in quinoa (Chenopodium quinoa): importance and possible action mechanisms of the seed coat. Seed Sci Res, 2015, 25: 267-275

[16] Chaganti VN, Ganjegunte GK. Quinoa growth and yield performance under salinity stress in arid West Texas. Agrosyst Geosci Environ, 2024, 7: e20493

[17] Chiurugwi T, Kemp S, Powell W, Hickey LT. Speed breeding orphan crops. Theor Appl Genet, 2018

[18] Choukr-Allah Ret al.. Quinoa for marginal environments: toward future food and nutritional security in MENA and Central Asia regions. Front Plant Sci, 2016, 7: 346

[19] Dassanayake M, Larkin JC. Making plants break a sweat: the structure, function, and evolution of plant salt glands. Front Plant Sci, 2017, 8: 406

[20] Dommes AB, Gross T, Herbert DB, Kivivirta KI, Becker A. Virus-induced gene silencing: empowering genetics in non-model organisms. J Exp Bot, 2019, 70: 757-770

[21] Eustis A, Murphy KM, Barrios-Masias FH. Leaf gas exchange performance of ten quinoa genotypes under a simulated heat wave. Plants (Basel), 2020, 9: 81

[22] FAO. State of the art report on quinoa around the world in 2013, 2013, Rome, Italy

[23] FAO (2024) FAO launches first major global assessment of salt-affected soils in 50 years. https://www.fao.org/newsroom/detail/fao-launches-first-major-global-assessment-of-salt-affected-soils-in-50-years/en

[24] Farooq MAet al.. Artificial intelligence in plant breeding. Trends Genet, 2024, 40: 891-908

[25] Flowers TJ, Colmer TD. Salinity tolerance in halophytes. New Phytol, 2008, 179: 945-963

[26] Flowers TJ, Galal HK, Bromham L. Evolution of halophytes: multiple origins of salt tolerance in land plants. Funct Plant Biol, 2010, 37: 604-612

[27] Fondevilla S, Calderon-Gonzalez A, Rojas-Panadero B, Cruz V, Matias J. Genome-wide association study, combined with bulk segregant analysis, identify plant receptors and defense related genes as candidate genes for downy mildew resistance in quinoa. BMC Plant Biol, 2024, 24: 594

[28] Fuentes FF, Bazile D, Bhargava A, Martínez EA. Implications of farmers' seed exchanges for on-farm conservation of quinoa, as revealed by its genetic diversity in Chile. J Agric Sci, 2012, 150: 702-716

[29] Godfray HCet al.. Food security: the challenge of feeding 9 billion people. Science, 2010, 327: 812-818

[30] Gómez MB, Castro PA, Mignone C, Bertero HD. Can yield potential be increased by manipulation of reproductive partitioning in quinoa (Chenopodium quinoa)? Evidence from gibberellic acid synthesis inhibition using Paclobutrazol. Funct Plant Biol, 2011, 38: 420-430

[31] Gomez MJR, Magro PC, Blazquez MR, Maestro-Gaitan I, Iniguez FMS, Sobrado VC, Prieto JM. Nutritional composition of quinoa leafy greens: an underutilized plant-based food with the potential of contributing to current dietary trends. Food Res Int, 2024, 178: 113862

[32] Gubler F, Millar AA, Jacobsen JV. Dormancy release, ABA and pre-harvest sprouting. Curr Opin Plant Biol, 2005, 8: 183-187

[33] Guo Yet al.. Analysis of root response mechanism of quinoa seedlings to waterlogging stress based on metabolome. J Plant Growth Regul, 2024, 43: 2251-2264

[34] Habib Z, Ijaz S, Haq IU, Hashem A, Avila-Quezada GD, Abd Allah EF, Khan NA. Empirical Phenotyping and Genome-Wide Association Study Reveal the Association of Panicle Architecture with Yield in Chenopodium Quinoa. Front Microbiol, 2024, 15: 1349239

[35] Hariadi Y, Marandon K, Tian Y, Jacobsen SE, Shabala S. Ionic and osmotic relations in quinoa (Chenopodium quinoa Willd.) plants grown at various salinity levels. J Exp Bot, 2011, 62: 185-193

[36] Hedrich R, Shabala S. Stomata in a saline world. Curr Opin Plant Biol, 2018, 46: 87-95

[37] Hinojosa L, Gonzalez JA, Barrios-Masias FH, Fuentes F, Murphy KM. Quinoa abiotic stress responses: a review. Plants (Basel), 2018, 7: 106

[38] Hinojosa L, Matanguihan JB, Murphy KM. Effect of high temperature on pollen morphology, plant growth and seed yield in quinoa. J Agron Crop Sci, 2019, 205: 33-45

[39] Hinojosa L, Sanad M, Jarvis DE, Steel P, Murphy K, Smertenko A. Impact of heat and drought stress on peroxisome proliferation in quinoa. Plant J, 2019, 99: 1144-1158

[40] Hirabayashi Yet al.. Global flood risk under climate change. Nat Clim Chang, 2013, 3: 816-821

[41] Hua K, Zhang J, Botella JR, Ma C, Kong F, Liu B, Zhu JK. Perspectives on the application of genome-editing technologies in crop breeding. Mol Plant, 2019, 12: 1047-1059

[42] Huang Het al.. Quinoa greens as a novel plant food: a review of its nutritional composition, functional activities, and food applications. Crit Rev Food Sci Nutr, 2025, 65: 3665-3685

[43] Imamura T, Takagi H, Miyazato A, Ohki S, Mizukoshi H, Mori M. Isolation and characterization of the betalain biosynthesis gene involved in hypocotyl pigmentation of the allotetraploid Chenopodium quinoa. Biochem Biophys Res Commun, 2018, 496: 280-286

[44] Jacobsen SE, Monteros C, Christiansen JL, Bravo LA, Corcuera LJ, Mujica A. Plant responses of quinoa (Chenopodium quinoa Willd.) to frost at various phenological stages. Eur J Agron, 2005, 22: 131-139

[45] Jacobsen SE, Monteros C, Corcuera LJ, Bravo LA, Christiansen JL, Mujica A. Frost resistance mechanisms in quinoa (Chenopodium quinoa Willd.). Eur J Agron, 2007, 26: 471-475

[46] Jacobsen S-E, Liu F, Jensen CR. Does root-sourced ABA play a role for regulation of stomata under drought in quinoa (Chenopodium quinoa Willd.). Sci Hortic, 2009, 122: 281-287

[47] Jaggi KEet al.. A pangenome reveals LTR repeat dynamics as a major driver of genome evolution in Chenopodium. Plant Genome, 2025, 18: e70010

[48] Jarvis DEet al.. The genome of Chenopodium quinoa. Nature, 2017, 542: 307-312

[49] Jiang Get al.. Mechanisms of flavonoids in quinoa's response to flooding stress in grain filling stage. Front Plant Sci, 2025, 16: 1565697

[50] Kammann CI, Linsel S, Gossling JW, Koyro HW. Influence of biochar on drought tolerance of Chenopodium quinoa Willd and on soil-plant relations. Plant Soil, 2011, 345: 195-210

[51] Kasajima I, Ito M, Yamagishi N, Yoshikawa N (2017) Apple Latent Spherical Virus (ALSV) vector as a tool for reverse genetic studies and non-transgenic breeding of a variety of crops. In: Rajewsky N, Jurga S, Barciszewski J (eds) Plant Epigenetics. Springer Nature, Cham. https://doi.org/10.1007/978-3-319-55520-1_25

[52] Kiani-Pouya Aet al.. Epidermal bladder cells confer salinity stress tolerance in the halophyte quinoa and Atriplex species. Plant Cell Environ, 2017, 40: 1900-1915

[53] Kiani-Pouya A, Rasouli F, Bazihizina N, Zhang H, Hedrich R, Shabala S. A large-scale screening of quinoa accessions reveals an important role of epidermal bladder cells and stomatal patterning in salinity tolerance. Environ Exp Bot, 2019, 168: 103885

[54] Killi D, Haworth M. Diffusive and metabolic constraints to photosynthesis in quinoa during drought and salt stress. Plants (Basel), 2017

[55] Kobayashi Y, Fujita Y. Epidermal bladder cells play a role in water retention in quinoa leaves. Plant Biotechnol, 2024

[56] Kobayashi Yet al.. CqHKT1 and CqSOS1 mediate genotype-dependent Na(+) exclusion under high salinity conditions in quinoa. Front Plant Sci, 2025, 16: 1597647

[57] Kumar A, Dames JF, Gupta A, Sharma S, Gilbert JA, Ahmad P. Current developments in arbuscular mycorrhizal fungi research and its role in salinity stress alleviation: a biotechnological perspective. Crit Rev Biotechnol, 2015, 35: 461-474

[58] Lenser T, Theissen G. Molecular mechanisms involved in convergent crop domestication. Trends Plant Sci, 2013, 18: 704-714

[59] Lesjak J, Calderini DF. Increased night temperature negatively affects grain yield, biomass and grain number in Chilean quinoa. Front Plant Sci, 2017, 8: 352

[60] Liu HJ, Yan J. Crop genome-wide association study: a harvest of biological relevance. Plant J, 2019, 97: 8-18

[61] Loc Nguyen Vet al.. Impact of genotypes, environmental stresses, and genotype by environment interactions on growth and yield of quinoa at flowering stage. PLoS ONE, 2025, 20: e0331652

[62] Lopez-Marques RLet al.. Prospects for the accelerated improvement of the resilient crop quinoa. J Exp Bot, 2020, 71: 5333-5347

[63] Ludwig CD, Maughan PJ, Jellen EN, Davis TM (2025) The genome of Chenopodium ficifolium: developing genetic resources and a diploid model system for allotetraploid quinoa bioRxiv:2025.2001.2017.633571 https://doi.org/10.1101/2025.01.17.633571

[64] Mangelson Het al.. The genome of Chenopodium pallidicaule : an emerging Andean super grain. Appl Plant Sci, 2019, 7 e11300

[65] Mansour MMF, Ali EF. Evaluation of proline functions in saline conditions. Phytochemistry, 2017, 140: 52-68

[66] Matías J, Rodríguez MJ, Cruz V, Calvo P, Reguera M. Heat stress lowers yields, alters nutrient uptake and changes seed quality in quinoa grown under Mediterranean field conditions. J Agron Crop Sci, 2021, 207: 481-491

[67] McGinty EM, Murphy KM, Hauvermale AL. Seed dormancy and preharvest sprouting in quinoa (Chenopodium quinoa Willd.). Plants (Basel), 2021, 10: 458

[68] Miranda-Apodaca J, Agirresarobe A, Munoz-Rueda A, Perez-Lopez U. Organ-specific epidermal bladder cell contribution to quinoa's performance. Physiol Plant, 2025, 177: e70652

[69] Mizuno Net al.. The genotype-dependent phenotypic landscape of quinoa in salt tolerance and key growth traits. DNA Res, 2020, 27: dsaa022

[70] Moog MWet al.. The epidermal bladder cell-free mutant of the salt-tolerant quinoa challenges our understanding of halophyte crop salinity tolerance. New Phytol, 2022, 236: 1409-1421

[71] Moog MWet al.. Epidermal bladder cells as a herbivore defense mechanism. Curr Biol, 2023, 33(4662–4673): e4666

[72] Morton MJL, Awlia M, Al-Tamimi N, Saade S, Pailles Y, Negrao S, Tester M. Salt stress under the scalpel - dissecting the genetics of salt tolerance. Plant J, 2019, 97: 148-163

[73] Murphy KM, Bazile D, Kellogg J, Rahmanian M. development of a worldwide consortium on evolutionary participatory breeding in quinoa. Front Plant Sci, 2016, 7: 608

[74] Nguyen VLet al.. Genotype by environment interaction across water regimes in relation to cropping season response of quinoa ( Chenopodium quinoa ). PLoS ONE, 2024, 19: e0309777

[75] Nonogaki M, Nonogaki H. Prevention of preharvest sprouting through hormone engineering and germination recovery by chemical biology. Front Plant Sci, 2017, 8: 90

[76] Nordborg M, Weigel D. Next-generation genetics in plants. Nature, 2008, 456: 720-723

[77] Ogata Tet al.. Virus-mediated transient expression techniques enable functional genomics studies and modulations of betalain biosynthesis and plant height in quinoa. Front Plant Sci, 2021, 12: 643499

[78] Palacios MB, Rizzo AJ, Heredia TB, Roqueiro G, Maldonado S, Murgida DH, Burrieza HP (2024) Structure, ultrastructure and cation accumulation in quinoa epidermal bladder cell complex under high saline stress. Protoplasma. https://doi.org/10.1007/s00709-023-01922-x

[79] Patiranage DSet al.. Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history. ELIFE, 2022, 11: e66873

[80] Pitzschke A. Molecular dynamics in germinating, endophyte-colonized quinoa seeds. Plant Soil, 2018, 422: 135-154

[81] Polturak G, Aharoni A. La Vie en Rose": Biosynthesis, sources, and applications of betalain pigments. Mol Plant, 2018, 11: 7-22

[82] Porras-Murillo R, Zhong JX, Schmöckel SM. Tissue culture and genetic transformation in quinoa (Chenopodium quinoa)-a mini-review. Plant Cell Tiss Org, 2025, 163: 1-20

[83] Prado FE, Boero C, Gallardo M, González JA. Effect of NaCl on germination, growth, and soluble sugar content in Chenopodium quinoa Willd. seeds. Bot Bull Acad Sin, 2000, 41: 27-34

[84] Rahman Het al.. Mining genomic regions associated with agronomic and biochemical traits in quinoa through GWAS. Sci Rep, 2024, 14: 9205

[85] Rasouli F, Kiani-Pouya A, Zhang H, Shabala S (2021) Mechanisms of Salinity Tolerance in Quinoa. In: Varma A (ed) Biology and Biotechnology of Quinoa: Super Grain for Food Security. Springer Nature, Singapore. https://doi.org/10.1007/978-981-16-3832-9_11

[86] Ren Get al.. Nutrient composition, functional activity and industrial applications of quinoa ( Chenopodium quinoa Willd.). Food Chem, 2023, 410: 135290

[87] Rey Eet al.. A chromosome-scale assembly of the quinoa genome provides insights into the structure and dynamics of its subgenomes. Commun Biol, 2023, 6: 1263

[88] Rojas W, Pinto M. Murphy K, Matanguihan J. Ex Situ Conservation of Quinoa: The Bolivian Experience. Quinoa: Improvement and Sustainable Production, 2015, New Jersey, USA, John Wiley & Sons Inc125-160

[89] Roman VJ, den Toom LA, Gamiz CC, van der Pijl N, Visser RGF, van Loo EN, van der Linden CG. Differential responses to salt stress in ion dynamics, growth and seed yield of European quinoa varieties. Environ Exp Bot, 2020, 177: 104146

[90] Rosa M, Hilal M, Gonzalez JA, Prado FE. Low-temperature effect on enzyme activities involved in sucrose-starch partitioning in salt-stressed and salt-acclimated cotyledons of quinoa (Chenopodium quinoa Willd.) seedlings. Plant Physiol Biochem, 2009, 47: 300-307

[91] Ruffino AMC, Rosa M, Hilal M, González JA, Prado FE. The role of cotyledon metabolism in the establishment of quinoa (Chenopodium quinoa) seedlings growing under salinity. Plant Soil, 2010, 326: 213-224

[92] Ruiz KB, Rapparini F, Bertazza G, Silva H, Torrigiani P, Biondi S. Comparing salt-induced responses at the transcript level in a salares and coastal-lowlands landrace of quinoa (Chenopodium quinoa Willd). Environ Exp Bot, 2017, 139: 127-142

[93] Sandell FL, Holzweber T, Street NR, Dohm JC, Himmelbauer H. Genomic basis of seed colour in quinoa inferred from variant patterns using extreme gradient boosting. Plant Biotechnol J, 2024, 22: 1312-1324

[94] Santos J, Al-Azzawi M, Aronson J, Flowers TJ. eHALOPH a database of salt-tolerant plants: helping put halophytes to work. Plant Cell Physiol, 2016, 57: e10

[95] Sasidharan Ret al.. Signal dynamics and interactions during flooding stress. Plant Physiol, 2018, 176: 1106-1117

[96] Shabala S, Bose J, Hedrich R. Salt bladders: do they matter?. Trends Plant Sci, 2014, 19: 687-691

[97] Sidorov V, Maughan PJ, Yang P. The development of an in vitro floral culture transformation system for quinoa. In Vitro Cell Dev Biol, 2024

[98] Singh SK, Wu X, Shao C, Zhang H. Microbial enhancement of plant nutrient acquisition. Stress Biol, 2022, 2 3

[99] Tai Let al.. Pre-harvest sprouting in cereals: genetic and biochemical mechanisms. J Exp Bot, 2021, 72(8): 2857-2876

[100] Tovar JCet al.. Heating quinoa shoots results in yield loss by inhibiting fruit production and delaying maturity. Plant J, 2020, 102: 1058-1073

[101] Tovar JC, Berry JC, Quillatupa C, Castillo SE, Acosta-Gamboa L, Fahlgren N, Gehan MA. Heat stress changes mineral nutrient concentrations in Chenopodium quinoa seed. Plant Direct, 2022, 6: e384

[102] Vásquez SC, Molina-Müller M, Murquincho L, Loja K, Granja F, Capa-Morocho M, Oviedo W (2025) Phenological stage determines quinoa yield losses under waterlogging. Paper presented at the ValSe & CICLA 2025

[103] Vieira CB, Ferreira JFS, Sandhu D, Sepsenwol S, Freire M. Spinach ( Spinacia oleracea ) has epidermal bladder cells and exhibits characteristics of a facultative halophyte. Commun Biol, 2025

[104] Villacres E, Quelal M, Galarza S, Iza D, Silva E. Nutritional value and bioactive compounds of leaves and grains from quinoa (Chenopodium quinoa Willd.). Plants (Basel), 2022, 11: 213

[105] Wang Xet al.. Identification and core gene-mining of weighted gene co-expression network analysis-based co-expression modules related to flood resistance in quinoa seedlings. BMC Genomics, 2024, 25: 728

[106] Wang S, Zhang L, Guo H, Feng S, Bao A-K. The salt bladder is essential for Atriplex canescens in response to salinity by regulating the ion homeostasis and water balance. Plant Soil, 2025, 514: 823-840

[107] Wang Xet al.. Joint analysis of transcriptome and metabolome on the accumulation mechanism of flavonoids in quinoa seedlings under flooding stress. BMC Plant Biol, 2025, 25: 852

[108] Weiss Tet al.. Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis. Nat Plants, 2025

[109] Xiao X, Meng F, Satheesh V, Xi Y, Lei M. An Agrobacterium-mediated transient expression method contributes to functional analysis of a transcription factor and potential application of gene editing in Chenopodium quinoa. Plant Cell Rep, 2022, 41: 1975-1985

[110] Xie Het al.. Combined transcriptomic and metabolomic analyses of high temperature stress response of quinoa seedlings. BMC Plant Biol, 2023, 23: 292

[111] Xie Y, Liu J, Zheng K, Chen Y, Zhu M. Efficient in vitro regeneration and overcoming premature senescence of Chenopodium quinoa willd. Sci Rep, 2025, 15: 19093

[112] Xu Yet al.. Enhancing genetic gain through genomic selection: from livestock to plants. Plant Commun, 2020, 1(1): 100005

[113] Xu Yet al.. Smart breeding driven by big data, artificial intelligence, and integrated genomic-enviromic prediction. Mol Plant, 2022, 15: 1664-1695

[114] Xu Jet al.. Wild relatives to improve heat tolerance of cultivated quinoa ( Chenopodium quinoa ): pollen viability and grain number. J Exp Bot, 2025, 76: 5117-5128

[115] Yang A, Akhtar SS, Amjad M, Iqbal S, Jacobsen SE. Growth and physiological responses of quinoa to drought and temperature stress. J Agron Crop Sci, 2016, 202: 445-453

[116] Yasui Yet al.. Draft genome sequence of an inbred line of Chenopodium quinoa , an allotetraploid crop with great environmental adaptability and outstanding nutritional properties. DNA Res, 2016, 23: 535-546

[117] Yoshida T, Ishikawa M, Toki S, Ishibashi K. Heritable tissue-culture-free gene editing in Nicotiana benthamiana through viral delivery of spCas9 and sgRNA. Plant Cell Physiol, 2024, 65: 1743-1750

[118] Young LAet al.. A chromosome-scale reference of Chenopodium watsonii helps elucidate relationships within the North American A-genome Chenopodium species and with quinoa. Plant Genome, 2023, 16: e20349

[119] Zhang Tet al.. Development of novel InDel markers and genetic diversity in Chenopodium quinoa through whole-genome re-sequencing. BMC Genomics, 2017, 18: 685

[120] Zhang H, Li Y, Zhu JK. Developing naturally stress-resistant crops for a sustainable agriculture. Nat Plants, 2018, 4: 989-996

[121] Zou Cet al.. A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value. Cell Res, 2017, 27: 1327-1340

[122] Zurbriggen MD, Hajirezaei MR, Carrillo N. Engineering the future. Development of transgenic plants with enhanced tolerance to adverse environments. Biotechnol Genet Eng Rev, 2010, 27: 33-56

Funding

Science and Technology Department of Xinjiang Uygur Autonomous Region(2022B02010-1)

Key Technologies Research and Development Program(2022YFF1003403-4)

National Natural Science Foundation of China(32441015)

RIGHTS & PERMISSIONS

The Author(s)