Dynamical network biomarkers for identifying critical transitions and their driving networks of biologic processes

Abstract

Non-smooth or even abrupt state changes exist during many biological processes, e.g., cell differentiation processes, proliferation processes, or even disease deterioration processes. Such dynamics generally signals the emergence of critical transition phenomena, which result in drastic changes of system states or eventually qualitative changes of phenotypes. Hence, it is of great importance to detect such transitions and further reveal their molecular mechanisms at network level. Here, we review the recent advances on dynamical network biomarkers (DNBs) as well as the related theoretical foundation, which can identify not only early signals of the critical transitions but also their leading networks, which drive the whole system to initiate such transitions. In order to demonstrate the effectiveness of this novel approach, examples of complex diseases are also provided to detect pre-disease stage, for which traditional methods or biomarkers failed.

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ACKNOWLEGEMENTS

The work was supported by the National Natural Science Foundation of China under Nos. 61072149, 61134013, 91029301 and 11241002, and by the Chief Scientist Program of SIBS of CAS with No. 2009CSP002. The work was also supported by Shanghai Pujiang Program, the Knowledge Innovation Program of CAS (No. KSCX2-EW-R-01), and 863 project (No. 2012AA020406), the National Center for Mathematics and Interdisciplinary Sciences of CAS, and the FIRST program from JSPS initiated by CSTP.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg