Protein & Cell >

2010 , Vol. 1 >Issue 7: 656 - 663

DOI: https://doi.org/10.1007/s13238-010-0083-1

Research articles

RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities

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  • 1.Key Laboratory of Infection and Immunity of Chinese Academy of Sciences, the Institute of Biophysics, Beijing 100101, China；Graduate University of the Chinese Academy of Sciences, Beijing 100080, China; 2.Key Laboratory of Infection and Immunity of Chinese Academy of Sciences, the Institute of Biophysics, Beijing 100101, China;

Published date: 01 Jul 2010

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Abstract

RING finger protein 152 (RNF152) is a novel RING finger protein and has not been well characterized. We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity. It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain. RNF152 is localized in lysosomes and co-localized with LAMP3, a lysosome marker. Moreover, over-expression of RNF152 in Hela cells induces apoptosis. These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities. It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis.

Key words： RNF152; RING finger; ubiquitinate; apoptosis

Cite this article

Songling Zhang, Wei Wu, Yanfang Wu, Jiyan Zheng, Talin Suo, Hong Tang, Jie Tang, . RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities[J]. Protein & Cell, 2010 , 1(7) : 656 -663 . DOI: 10.1007/s13238-010-0083-1

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