1.Key Laboratory of Infection
and Immunity of Chinese Academy of Sciences, the Institute of Biophysics,
Beijing 100101, China；Graduate University of
the Chinese Academy of Sciences, Beijing 100080, China; 2.Key Laboratory of Infection
and Immunity of Chinese Academy of Sciences, the Institute of Biophysics,
Beijing 100101, China;
Show less
History+
Published Online
2010-07-01
PDF
(426KB)
Abstract
RING finger protein 152 (RNF152) is a novel RING finger protein and has not been well characterized. We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity. It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain. RNF152 is localized in lysosomes and co-localized with LAMP3, a lysosome marker. Moreover, over-expression of RNF152 in Hela cells induces apoptosis. These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities. It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis.
Songling Zhang, Wei Wu, Yanfang Wu, Jiyan Zheng, Talin Suo, Hong Tang, Jie Tang,.
RNF152, a novel lysosome localized E3 ligase
with pro-apoptotic activities.
Protein Cell, 2010, 1(7): 656-663 DOI:10.1007/s13238-010-0083-1
PDF
(426KB)
