RNF152, a novel lysosome localized E3 ligase
with pro-apoptotic activities

doi:10.1007/s13238-010-0083-1

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Protein Cell ›› 2010, Vol. 1 ›› Issue (7) : 656-663. DOI: 10.1007/s13238-010-0083-1

Research articles

RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities

Songling Zhang¹,Wei Wu²,Yanfang Wu²,Jiyan Zheng²,Talin Suo²,Hong Tang²,Jie Tang²,

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Abstract

RING finger protein 152 (RNF152) is a novel RING finger protein and has not been well characterized. We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity. It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain. RNF152 is localized in lysosomes and co-localized with LAMP3, a lysosome marker. Moreover, over-expression of RNF152 in Hela cells induces apoptosis. These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities. It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis.

Keywords

RNF152 / RING finger / ubiquitinate / apoptosis

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Songling Zhang, Wei Wu, Yanfang Wu, Jiyan Zheng, Talin Suo, Hong Tang, Jie Tang,. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. Protein Cell, 2010, 1(7): 656‒663 https://doi.org/10.1007/s13238-010-0083-1