The secretory function of adipose tissues in metabolic regulation

  • Yang Liu ,
  • Shu-Wen Qian ,
  • Yan Tang ,
  • Qi-Qun Tang
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  • Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China
qqtang@shmu.edu.cn

Received date: 01 Nov 2023

Revised date: 04 Jan 2024

Accepted date: 19 Jan 2024

Published date: 22 Jul 2024

Copyright

2024 The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.

Abstract

In addition to their pivotal roles in energy storage and expenditure, adipose tissues play a crucial part in the secretion of bioactive molecules, including peptides, lipids, metabolites, and extracellular vesicles, in response to physiological stimulation and metabolic stress. These secretory factors, through autocrine and paracrine mechanisms, regulate various processes within adipose tissues. These processes include adipogenesis, glucose and lipid metabolism, inflammation, and adaptive thermogenesis, all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment. A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite, cognitive function, energy expenditure, insulin secretion and sensitivity, gluconeogenesis, cardiovascular remodeling, and exercise capacity. In this review, we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating metabolic homeostasis. Furthermore, we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions, shedding light on potential pharmacological treatment strategies for related diseases.

Cite this article

Yang Liu , Shu-Wen Qian , Yan Tang , Qi-Qun Tang . The secretory function of adipose tissues in metabolic regulation[J]. Life Metabolism, 2024 , 3(2) : loae003 . DOI: 10.1093/lifemeta/loae003

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