Life Metabolism >

2022 , Vol. 1 >Issue 1: 81 - 93

DOI: https://doi.org/10.1093/lifemeta/loac009

Original Article

Splicing factor PRP-19 regulates mitochondrial stress response

  • Peixue Xia 1,2 ,
  • Liankui Zhou 1,2 ,
  • Jialiang Guan 3 ,
  • Wanqiu Ding 1 ,
  • Ying Liu , 1,2,4
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  • 1. State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China
  • 2. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
  • 3. PKU-Tsinghua-NIBS Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
  • 4. Beijing Advanced Innovation Center for Genomics, Beijing, China

Received date: 19 Jan 2022

Revised date: 25 May 2022

Accepted date: 18 Jun 2022

Copyright

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.
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Abstract

Animals respond to mitochondrial perturbation by activating the mitochondrial unfolded protein response (UPRmt) to induce the transcription of mitochondrial stress response genes. In Caenorhabditis elegans, activation of UPRmt allows the animals to maintain organismal homeostasis, activate the innate immune response, and promote lifespan extension. Here, we show that splicing factors such as Precursor RNA processing 19 (PRP-19) are required for the induction of UPRmt in C. elegans. PRP-19 also modulates mitochondrial perturbation-induced innate immune response and lifespan extension. Knockdown of PRP-19 in mammalian cells suppresses UPRmt activation and disrupts the mitochondrial network. These findings reveal an evolutionarily conserved mechanism that maintains mitochondrial homeostasis and controls innate immunity and lifespan through splicing factors.

Key words： mitochondria; unfolded protein response; stress response; splicing; lifespan

Cite this article

Peixue Xia , Liankui Zhou , Jialiang Guan , Wanqiu Ding , Ying Liu . Splicing factor PRP-19 regulates mitochondrial stress response[J]. Life Metabolism, 2022 , 1(1) : 81 -93 . DOI: 10.1093/lifemeta/loac009

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