Splicing factor PRP-19 regulates mitochondrial stress response
Received date: 19 Jan 2022
Revised date: 25 May 2022
Accepted date: 18 Jun 2022
Copyright
Animals respond to mitochondrial perturbation by activating the mitochondrial unfolded protein response (UPRmt) to induce the transcription of mitochondrial stress response genes. In Caenorhabditis elegans, activation of UPRmt allows the animals to maintain organismal homeostasis, activate the innate immune response, and promote lifespan extension. Here, we show that splicing factors such as Precursor RNA processing 19 (PRP-19) are required for the induction of UPRmt in C. elegans. PRP-19 also modulates mitochondrial perturbation-induced innate immune response and lifespan extension. Knockdown of PRP-19 in mammalian cells suppresses UPRmt activation and disrupts the mitochondrial network. These findings reveal an evolutionarily conserved mechanism that maintains mitochondrial homeostasis and controls innate immunity and lifespan through splicing factors.
Key words: mitochondria; unfolded protein response; stress response; splicing; lifespan
Peixue Xia , Liankui Zhou , Jialiang Guan , Wanqiu Ding , Ying Liu . Splicing factor PRP-19 regulates mitochondrial stress response[J]. Life Metabolism, 2022 , 1(1) : 81 -93 . DOI: 10.1093/lifemeta/loac009
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