Manganese therapy for dyslipidemia and plaque reversal in murine models

Yawei Wang , Xin Feng , Wenjing Zhou , Runze Huang , Yating Hu , Hui Hui , Jie Tian , Xiao Wang , Xiao-Wei Chen

Life Metabolism ›› 2023, Vol. 2 ›› Issue (6) : 320 -325.

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Life Metabolism ›› 2023, Vol. 2 ›› Issue (6) : 320 -325. DOI: 10.1093/lifemeta/load040
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Manganese therapy for dyslipidemia and plaque reversal in murine models

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Yawei Wang, Xin Feng, Wenjing Zhou, Runze Huang, Yating Hu, Hui Hui, Jie Tian, Xiao Wang, Xiao-Wei Chen. Manganese therapy for dyslipidemia and plaque reversal in murine models. Life Metabolism, 2023, 2(6): 320-325 DOI:10.1093/lifemeta/load040

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References

[1]

Goldstein JL, Brown MS. A century of cholesterol and coronaries: from plaques to genes to statins. Cell 2015;161:161–72.

[2]

Bentzon JF, Otsuka F, Virmani R et al. Mechanisms of plaque formation and rupture. Circ Res 2014;114:1852–66.

[3]

Brandts J, Ray KK. Novel and future lipid-modulating therapies for the prevention of cardiovascular disease. Nat Rev Cardiol 2023;20:600–616.

[4]

Fisher EA, Ginsberg HN. Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J Biol Chem 2002;277:17377–80.

[5]

Jones B, Jones EL, Bonney SA et al. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet 2003;34:29–31.

[6]

Wang X, Chen XW. Cargo receptor-mediated ER export in lipoprotein secretion and lipid homeostasis. Csh Perspect Biol 2023;15:a041260.

[7]

Ginsberg HN. ApoB SURFs a ride from the ER to the Golgi. Cell Metab 2021;33:231–3.

[8]

Wang X, Wang H, Xu B et al. Receptor-mediated ER export of lipoproteins controls lipid homeostasis in mice and humans. Cell Metab 2021;33:350–66.e7.

[9]

Huang D, Xu B, Liu L et al. TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis. Cell Metab 2021;33:1655–70.e8.

[10]

Wang X, Huang R, Wang Y et al. Manganese regulation of COPII condensation controls circulating lipid homeostasis. Nat Cell Biol 2023.

[11]

Chen P, Bornhorst J, Aschner M. Manganese metabolism in humans. Front Biosci (Landmark Ed) 2018;23:1655–79.

[12]

Tong W, Hui H, Shang W et al. Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles. Theranostics 2021;11:506–21.

[13]

Horning KJ, Caito SW, Tipps KG et al. Manganese is essential for neuronal health. Annu Rev Nutr 2015;35:71–108.

[14]

Bomb B, Kumawat DC, Bomb P et al. Effect of manganese on regression of atherosclerosis in cholesterol fed rabbits. J Assoc Physicians India 1988;36:149–50.

[15]

Wang L, Luo JY, Li B et al. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 2016;540:579–82.

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The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

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