Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects

Zhen Zhang; Hong-Ling Zhang; Da-Hai Yang; Qiang Hao; Hong-Wei Yang; De-Long Meng; Willem Meindert de Vos; Le-Luo Guan; Shu-Bin Liu; Tsegay Teame; Chen-Chen Gao; Chao Ran; Ya-Lin Yang; Yuan-Yuan Yao; Qian-Wen Ding; Zhi-Gang Zhou

doi:10.1002/imt2.181

iMeta ›› 2024, Vol. 3 ›› Issue (2) : 181 DOI: 10.1002/imt2.181

RESEARCH ARTICLE

Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects

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Abstract

•SpaC pilin acts as a causative factor of Lactobacillus rhamnosus GG-induced intestinal mucosa damage in zebrafish.

•Dietary SpaC directly induces intestinal pyroptosis by activating GSDMEa in zebrafish.

•Dietary SpaC induces gut microbial dysbiosis characterized by higher abundance of lipopolysaccharide (LPS)-producing gut microbes in zebrafish.

•LPS-producing gut microbes subsequently activate Gaspy2−GSDMEb pyroptosis pathway in zebrafish.

Keywords

intestinal mucosal damage / Lactobacillus rhamnosus GG / probiotic safety / SpaC / zebrafish

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Zhen Zhang, Hong-Ling Zhang, Da-Hai Yang, Qiang Hao, Hong-Wei Yang, De-Long Meng, Willem Meindert de Vos, Le-Luo Guan, Shu-Bin Liu, Tsegay Teame, Chen-Chen Gao, Chao Ran, Ya-Lin Yang, Yuan-Yuan Yao, Qian-Wen Ding, Zhi-Gang Zhou. Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta, 2024, 3(2): 181 DOI:10.1002/imt2.181