The gut microbiota-aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol-rich extracts from Sanghuangporus
Shi Zhong , Yu-Qing Sun , Jin-Xi Huo , Wen-Yi Xu , Ya-Nan Yang , Jun-Bo Yang , Wei-Jie Wu , Yong-Xin Liu , Chong-Ming Wu , You-Gui Li
iMeta ›› 2024, Vol. 3 ›› Issue (2) : 180
The gut microbiota-aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol-rich extracts from Sanghuangporus
•Sanghuangporus (SH) polyphenol extract potently alleviated symptoms of colon colitis in dextran sodium sulfate-induced colitis mice. •The gut microbiota especially Alistipes onderdonkii mediates the anticolitic effect of SH. •The SH-enriched microbial metabolite 5-hydroxyindole-3-acetic acid exhibited an anticolitic effect via the activation of the aryl hydrocarbon receptor. •The “gut microbiota-metabolites-signaling pathway” provides an effective perspective for the study of complex Chinese medicine systems.
5-hydroxyindole-3-acetic acid / aromatic hydrocarbon receptor / gut microbiota / inflammatory bowel disease / Sanghuangporus
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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