Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum
Peng Gao , Jianyou Wang , Chong Qiu , Huimin Zhang , Chen Wang , Ying Zhang , Peng Sun , Honglin Chen , Yin Kwan Wong , Jiayun Chen , Junzhe Zhang , Huan Tang , Qiaoli Shi , Yongping Zhu , Shengnan Shen , Guang Han , Chengchao Xu , Lingyun Dai , Jigang Wang
iMeta ›› 2024, Vol. 3 ›› Issue (2) : 176
Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum
•We identified the targets of artemisinin at different stages of the intraerythrocytic cycle of Plasmodium falciparum using a photoaffinity probe of artemisinin. •Artemisinin can interact with parasite proteins in vivo through both covalent and noncovalent mechanisms. •Artemisinin may exert its antimalarial effects by interfering with the parasite’s protein synthesis, glycolysis, and oxidative homeostasis pathways. •This study provides fresh insights into the mechanisms underlying artemisinin’s antimalarial effects and its protein targets.
antimalarial / artemisinin / chemical proteomics / intraerythrocytic cycle / photoaffinity probe
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
/
| 〈 |
|
〉 |
PDF
