Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae
Xiaoqian Lin , Tongyuan Hu , Zhinan Wu , Lingne Li , Yuhao Wang , Dingyang Wen , Xudong Liu , Wenxi Li , Hewei Liang , Xin Jin , Xun Xu , Jian Wang , Huanming Yang , Karsten Kristiansen , Liang Xiao , Yuanqiang Zou
iMeta ›› 2024, Vol. 3 ›› Issue (2) : 174
Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae
•Comprehensive genome analysis reveals underestimated species diversity and distinct functions of Lachnospiraceae. •Cataloging 1.5M genes highlights Lachnospiraceae’s significant role in the human gut microbiota, with potential novel species contributing. •Lachnospiraceae demonstrates a vast potential for synthesizing short-chain fatty acid (SCFA), producing secondary metabolites, and forming spores, which is promising for future studies and applications. •The abundance of Lachnospiraceae correlates inversely with diseases like atherosclerotic cardiovascular disease (ACVD) and inflammatory bowel disease (IBD), indicating a potential protective role.
genomic analysis / Lachnospiraceae / next-generation probiotics / probiotic functional predictions
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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