Storage-D: A user-friendly platform that enables practical and personalized DNA data storage

Xiaoluo Huang; Junting Cui; Wei Qiang; Jianwen Ye; Yu Wang; Xinying Xie; Yuanzhen Li; Junbiao Dai

doi:10.1002/imt2.168

iMeta ›› 2024, Vol. 3 ›› Issue (2) : 168 DOI: 10.1002/imt2.168

RESEARCH ARTICLE

Storage-D: A user-friendly platform that enables practical and personalized DNA data storage

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Abstract

•Deoxyribonucleic acid (DNA) data storage exhibits remarkable advantages, such as high density and long lifespan, and is suggested to be one of the most promising media for coping with future data storage crises.

•A user-friendly platform, “Storage-D” was developed, which enables users to store any format of practical data with personalized choice.

•Specifically, a new algorithm, named “Wukong” was developed, which contains a sizeable collection of codec pins that enables encoding data into any DNA sequence with considerable privacy.

•The “Wukong” algorithm shows overall better performance than earlier algorithms in encoding a suitable length of DNA sequence matching downstream biochemical working flow for in vitro and in vivo storage.

•The tool provides an open-frame for integrating other codec algorithms and can be easily connected to commercial DNA synthesis and sequencing platform for building a complete pipeline for practical data storage into DNA. The web server and codes of the platform are available at http://storage.dailab.xyz:16666/ and https://github.com/DNAstorage-iSynBio/Storage-D/, respectively.

Keywords

codec platform / DNA data storage / Storage-D,“Wukong”algorithm

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Xiaoluo Huang, Junting Cui, Wei Qiang, Jianwen Ye, Yu Wang, Xinying Xie, Yuanzhen Li, Junbiao Dai. Storage-D: A user-friendly platform that enables practical and personalized DNA data storage. iMeta, 2024, 3(2): 168 DOI:10.1002/imt2.168