Intestinal flora and pregnancy complications: Current insights and future prospects
Zhenyu Tian , Xinjie Zhang , Guixiang Yao , Jiajia Jin , Tongxue Zhang , Chunhua Sun , Zhe Wang , Qunye Zhang
iMeta ›› 2024, Vol. 3 ›› Issue (2) : 167
Intestinal flora and pregnancy complications: Current insights and future prospects
•Pregnancy complications critically affect maternal and child health, necessitating urgent research and therapeutic strategies to reduce health and socioeconomic impacts. •Gut microbiota dysbiosis in patients with various pregnancy complications acts as both a causal factor and a contributor to these conditions. •Gut microbiota-derived metabolites are involved in various pathophysiological pathways closely related to the pathogenesis of pregnancy complications, including intestinal barrier permeability, inflammatory responses, and glucose and lipid metabolism. •Emerging therapeutic strategies based on gut microbes show potential in treating pregnancy complications, yet there is a lack of evidence from randomized controlled trials (RCTs) to substantiate this approach.
gestational diabetes mellitus / gut microbiota / in utero colonization / microecological therapy / pre-eclampsia / pregnancy complications / sterile womb
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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