Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients
Baoquan Han , Yongyong Wang , Wei Ge , Junjie Wang , Shuai Yu , Jiamao Yan , Lei Hua , Xiaoyuan Zhang , Zihui Yan , Lu Wang , Jinxin Zhao , Cong Huang , Bo Yang , Yan Wang , Qian Ma , Yong Zhao , Hui Jiang , Yunqi Zhang , Shaolin Liang , Jianjuan Zhao , Zhongyi Sun , Wei Shen , Yaoting Gui
iMeta ›› 2024, Vol. 3 ›› Issue (2) : 166
Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients
•This study substantiates the potential clinical diagnostic utility of microbial composition and specific metabolites within seminal plasma for the asthenozoospermia (AZS) identification. •Divergent microbial compositions and metabolite profiles within seminal plasma are discernible across varying degrees of AZS severity. •Validation via in vitro and in vivo experiments corroborates hexadecanamide as a crucial metabolite influencing sperm motility in AZS, coupled with the dysregulation of target proteins (PAOX and CA2).
16s rDNA sequencing / asthenozoospermia / hexadecanamide / multi-omics analysis / seminal plasma metabolome / seminal plasma microbiota / sperm motility
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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