Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?

Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?

Doriana Oliveri, Giorgia Moschetti, Anna Griego, Edoardo Scarpa

Ibrain ›› 2024, Vol. 10 ›› Issue (2) : 225-230. DOI: 10.1002/ibra.12154

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Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?

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Abstract

Recent research has shown that tau protein can be passed to neighboring cells, leading to cellular senescence in the endothelial cells present in the central nervous system (CNS). This discovery could potentially open new doors for testing novel therapeutic compounds that specifically target senescent cells (senolytics) or for identifying new biomarkers that can enable early detection of tauopathies and dementia.

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brain / cellular senescence / tauopathies

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Doriana Oliveri, Giorgia Moschetti, Anna Griego, Edoardo Scarpa. Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?. Ibrain, 2024, 10(2): 225‒230 https://doi.org/10.1002/ibra.12154

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2024 2024 The Authors. Ibrain published by Affiliated Hospital of Zunyi Medical University (AHZMU) and Wiley-VCH GmbH.

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