Understanding the physics of DNA using nanoscale single-molecule manipulation

Abstract

Processes for decoding the genetic information in cells, includingtranscription, replication, recombination and repair, involve thedeformation of DNA from its equilibrium structures such as bending,stretching, twisting, and unzipping of the double helix. Single-moleculemanipulation techniques have made it possible to control DNA conformationand simultaneously detect the induced changes, revealing a rich varietyof mechanically-induced conformational changes and thermodynamic states.These single-molecule techniques helped us to reveal the physics ofDNA and the processes involved in the passing on of the genetic code.

Keywords

single-molecule manipulation / the physics of DNA

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