Advances in surface plasmon resonance-based high throughput biochips

Abstract

This article reviews our recent advances in surface plasmon resonance (SPR) based biochips. It includes four issues, which are the preparation and characterization of high quality gold film, the preparation and characterization of self-assembled monolayer (SAM), dynamics of DNA adsorption on SAMs, and SPRbased microscopies. Numerous topics related to SPR, such as, the modeling of SPR by transmission matrix, effective medium theory, applications of SPR in biology, and SPR-based novel microscopies, are discussed. A novel electrochemical technique, which is extremely useful for the preparation and characterization of high quality SAMs, is also discussed.

Keywords

surface plasmon resonance / effective medium theory / self-assembled monolayer / electrochemical impedance spectroscopy / atomic force microscopy / SPR-based microscopy