In this article, poly(N-methyl acryloylglycine methyl ester) (PNMAME) was prepared as a novel thermo-sensitive material with a lower critical solution temperature (LCST) at around 49.5°C. The chemical structures of the monomer NMAME and PNMAME were characterized by 1H NMR and IR measurements. The LCST was investigated systematically as a function of PNMAME concentration, inorganic salt solution and pH value. The results indicatedthat LCST of PNMAME was obviously dependent on PNMAME concentration and pH. The LCST was increased with a decrease in pH value and PNMAME concentration. To obtain a thermo-sensitive hydrogel with the phase transition temperature close to human body temperature, the copolymerization was conducted between NMAME and N-acryloylglycine ethyl ester (NAGEE). The release behavior of caffeine was evaluated at different temperatures and contents of cross-linkers (N, N-methylenebis(acrylamide) (NMBA)). The increase of cross-linker content led to a decrease in the release rate of caffeine due to higher crossing density in the hydrogel network. In addition, a faster release of caffeine from the hydrogel with 3% NMBA at 37°C was found in contrast to that at 18°C.
Kui-Lin DENG, Hai-Bin ZHONG, Yi-Suo JIAO, Ting FAN, Xiao QIAO, Peng-Fei ZHANG, Xiao-Bo REN,
. Synthesis and characterization of a thermo-sensitive
poly( N -methyl acryloylglycine methyl
ester) used as a drug release carrier[J]. Frontiers of Materials Science, 2010
, 4(2)
: 164
-170
.
DOI: 10.1007/s11706-010-0032-1